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Tolrestat
go.drugbank.com/drugs/DB02383ApprovedWithdrawnTolrestat (INN) (AY-27773) is an aldose reductase inhibitor which was approved for the control of certain diabetic complications. … While it was approved for marketed in several countries, it failed a Phase III trial in the U.S. due to toxicity and never received FDA approval.
Zanidatamab zovodotin
go.drugbank.com/drugs/DB15472ExperimentalAccording to Zymeworks, "ZW49 (zanidatamab zovodotin) is a bispecific anti-HER2 ADC that is based on the same antibody framework as [ZW25] but armed with a cytotoxic payload." … [L8234] It is being investigated for several indications characterized by HER2 expression including breast and gastric cancers that have progressed or are refractory to existing HER2-targeted therapies
Synonyms: anti-HER2 x HER2 ADCTelratolimod
go.drugbank.com/drugs/DB19590InvestigationalTelratolimod is a small molecule drug. The usage of the INN stem '-tolimod' in the name indicates that Telratolimod is a toll-like receptor (TLR) agonist. … Telratolimod is under investigation in clinical trial NCT06680479 (Safety and Immunogenicity of Stabilized CH505 TF chTrimer Vaccination in Adults Living With HIV-1 on Suppressive Antiretroviral Therapy
Icenticaftor
go.drugbank.com/drugs/DB21466InvestigationalIcenticaftor is a small molecule drug. … The usage of the INN stem '-caftor' in the name indicates that Icenticaftor is a Cystic fibrosis transmembrane regulator (CFTR) protein modulator, corrector, and amplifier.
Categories: Heterocyclic Compounds, 1-RingRezivertinib
go.drugbank.com/drugs/DB21471InvestigationalRezivertinib is a small molecule drug. The usage of the INN stem '-ertinib' in the name indicates that Rezivertinib is a epidermal growth factor receptor (EGFR) inhibitor. … Rezivertinib has a monoisotopic molecular weight of 486.24 Da.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingTuxobertinib
go.drugbank.com/drugs/DB21508InvestigationalTuxobertinib is a small molecule drug. The usage of the INN stem '-ertinib' in the name indicates that Tuxobertinib is a epidermal growth factor receptor (EGFR) inhibitor. … Tuxobertinib is under investigation in clinical trial NCT04209465 (A Study of BDTX-189, an Orally Available Allosteric ErbB Inhibitor, in Patients With Advanced Solid Tumors.).
Linvencorvir
go.drugbank.com/drugs/DB21544InvestigationalLinvencorvir is a small molecule drug. The usage of the INN stem '-corvir' in the name indicates that Linvencorvir is a core protein (Cp) inhibitor. … Linvencorvir is under investigation in clinical trial NCT04225715 (A Trial To Evaluate The Efficacy And Safety Of Multiple Combination Therapies In Participants With Chronic Hepatitis B).
Categories: Heterocyclic Compounds, 1-RingFipravirimat
go.drugbank.com/drugs/DB21578InvestigationalFipravirimat is a small molecule drug. The usage of the INN stem '-virimat' in the name indicates that Fipravirimat is a antiviral, disruptor of viral maturation. … Fipravirimat is under investigation in clinical trial NCT04493216 (A Dose-Range Finding Clinical Trial Study in Human Immunodeficiency Virus (HIV-1) Infected Treatment-Naive Adults).
Opnurasib
go.drugbank.com/drugs/DB21583InvestigationalOpnurasib is a small molecule drug. The usage of the INN stem '-rasib' in the name indicates that Opnurasib is a Ras protein inhibitor. … Opnurasib has a monoisotopic molecular weight of 525.2 Da.
Categories: Heterocyclic Compounds, 1-RingRelutrigine
go.drugbank.com/drugs/DB21614InvestigationalRelutrigine is a small molecule drug. The usage of the INN stem '-trigine' in the name indicates that Relutrigine is a sodium channel blocker, signal transduction modulator. … Relutrigine is under investigation in clinical trial NCT07010471 (A Clinical Trial for Participants With DEE to Assess Efficacy, Safety, Tolerability, and PK of Relutrigine).