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Ondansetron
go.drugbank.com/drugs/DB00904ApprovedInvestigationalWithdrawn[L5221] The FDA withdrew its approval for the use of all intravenous drug products containing more than 16 mg of ondansetron hydrochloride in a single dose, due to a high risk of QT prolongation. … A competitive serotonin type 3 receptor antagonist.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsProducts: BRYTEROL® TABLETAS X 8 MG, ONDANSETRON EGSomatostatin
go.drugbank.com/drugs/DB09099ApprovedInvestigationalWithdrawnThe actions of somatostatin are mediated via signalling pathways of G protein-coupled somatostatin receptors. … It is secreted by the D cells of the islets to inhibit the release of insulin and glucagon, and is also generated in the hypothalamus, where it inhibits the release of growth hormone and thyroid-stimulating
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsProducts: SOMATOSTATIN EUMEDICA 250 MCG IV INFÜZYON ICIN LIYOFILIZE TOZ ICEREN FLAKON, 1 ADET, SOMATOSAN 3 MG IV INFUZYON ICIN 1 AMPULTetanus immune globulin, human
go.drugbank.com/drugs/DB11604ApprovedInvestigationalTetanus Immune Globulin is manufactured from human plasma [FDA Label]. It contains antibodies against tetanus toxoid and is primarily used as prophylaxis against tetanus in wounded patients.
Products: IGANTET INJECTION 500 iu/2 ml, TETANUS GAMMA KEDRION ® 250 UI/1 MLLercanidipine
go.drugbank.com/drugs/DB00528ApprovedInvestigationalWithdrawnLercanidipine is a calcium channel blocker of the dihydropyridine class. It is sold under various commercial names including Zanidip.
Mixtures: ZANIPRESS 20 MG/20 MG FILM TABLET,90 ADET, Zanipril 20 mg/20 mg FilmtablettenCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsTelmisartan
go.drugbank.com/drugs/DB00966ApprovedInvestigationalsmooth muscle, ultimately leading to a reduction in arterial blood pressure. … Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular
Synonyms: 4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]biphenyl-2-carboxylic acid, 4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acidMixtures: RENANGIO PLUS®80 MG + 25 MG, MICARDIS® PLUS 80 MG/25 MGEstradiol valerate
go.drugbank.com/drugs/DB13956ApprovedInvestigationalVet approvedThe primary source of estrogen in normally cycling adult women is the ovarian follicle, which secretes 70 to 500 mcg of estradiol daily, depending on the phase of the menstrual cycle. … As a pro-drug of estradiol, estradiol acetate therefore has the same downstream effects within the body through binding to the Estrogen Receptor (ER) including ERα and ERβ subtypes, which are located in
Mixtures: MESIGYNA 5 MG+50 MG/1 ML ENJEKSIYONLUK COZELTI ICEREN KULLANIMA HAZIR ENJEKTÖR, VELBIENNE® 20Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 SubstratesRiluzole
go.drugbank.com/drugs/DB00740ApprovedInvestigationalRiluzole is marketed as Rilutek by Sanofi. … A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong the survival of patients with amyotrophic lateral sclerosis.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 SubstratesInternational brands: Xie Yi LiCarvedilol
go.drugbank.com/drugs/DB01136ApprovedInvestigationalCarvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker. … [L7889,L7892] The dual action of carvedilol is advantageous in combination therapies as moderate doses of 2 drugs have a decreased incidence of adverse effects compared to high dose monotherapy in the
Synonyms: (+-)-1-(Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanolMixtures: Co-Dilatrend 25 mg/12,5 mg - Filmtabletten, CARIVALAN 25/5Clomipramine
go.drugbank.com/drugs/DB01242ApprovedInvestigationalVet approvedTCAs also block histamine-H<sub>1</sub> receptors, α<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred … Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines.
Synonyms: 3-(3-chloro-5H-dibenzo[b,F]azepin-5-yl)-N,N-dimethylpropan-1-amine, 3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamineCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesTeriparatide
go.drugbank.com/drugs/DB06285ApprovedInvestigationalTeriparatide is a recombinant parathyroid hormone (PTH) analog and a potent osteoanabolic agent.[A251395] It is made up of the first amino(N)-terminal 34 amino acids of the human PTH. … [A251395] First approved in the United States in November 2002 and in Europe in April 2003,[A251400] teriparatide makes the first approved drug in a new category of osteoporosis therapy called anabolic
Categories: Sex Hormones and InsulinsSynonyms: PTH 1-34, PTH (1-34)