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Displaying results 6241 - 6250 of 10000 in total
  1. Drug

    Melengestrol

    go.drugbank.com/drugs/DB11529
    ExperimentalVet approved

    Melengestrol is a steroidal progestin and antineoplastic agent which was never marketed. An acylated derivative, melengestrol acetate, is used as a growth promoter in animals.

    Categories: Hormones, Hormone Substitutes, and Hormone Antagonists
  2. Drug

    PX-12

    go.drugbank.com/drugs/DB05448
    Investigational

    PX-12 (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits … Since high levels of Trx-1 have been associated with colorectal, gastric and lung cancers, PX-12 is indicated as a potential cancer treatment in combination with chemotherapy for patients with advanced

  3. Drug

    AVN-944

    go.drugbank.com/drugs/DB05500
    Investigational

    , DNA replication, apoptosis and cell cycle control. … AVN944 is a biotech drug that demonstrated a statistically meaningful impact on IMPDH and other proteins that are critical to activities in cancer cells, including nucleotide biosynthesis, energy and metabolism

  4. Drug

    Recombinant human kallikrein-1

    go.drugbank.com/drugs/DB19232
    Investigational

    Recombinant human kallikrein-1 is under investigation in clinical trial NCT01845064 (A Study to Evaluate the Safety and Effectiveness of DM199 in Healthy Subjects and Type 2 Diabetes Patients).

    Categories: Enzymes and Coenzymes, Amino Acids, Peptides, and Proteins
  5. Drug

    Bleomycin A6

    go.drugbank.com/drugs/DB12992
    Investigational

    It was shown that besides the antitumor effect, Bleomycin A6 had the ability to alter the tumor microenvironment and could contribute toward lung cancer relapse and metastasis on long-term treatment. … It was developed in China as an antineoplastic antibiotic. This drug participated in clinical trials for the treatment of Squamous Cell Lung Cancer.

    Categories: Amino Acids, Peptides, and Proteins
  6. Drug

    Depatuxizumab

    go.drugbank.com/drugs/DB12826
    Investigational

    Depatuxizumab has been used in trials studying the treatment and diagnostic of Adenocarcinoma and Advanced Solid Tumors.

    Categories: Amino Acids, Peptides, and Proteins
  7. Drug

    AZD-9684

    go.drugbank.com/drugs/DB05712
    Experimental

    AZD-9684 is the first member of a new anti-thrombotic class (CPU inhibitors). It is being developed by AstraZeneca.

  8. Drug

    Idursulfase beta

    go.drugbank.com/drugs/DB16190
    Investigational

    Idursulfase beta is under investigation in clinical trial NCT01645189 (Safety and Efficacy of Hunterase).

    Categories: Enzymes and Coenzymes, Alimentary Tract and Metabolism
  9. Drug

    Aldafermin

    go.drugbank.com/drugs/DB16086
    Investigational

    Study in Subjects With Nonalcoholic Steatohepatitis and Stage 2/3 Fibrosis (ALPINE 2/3)). … Aldafermin is under investigation in clinical trial NCT03912532 (Evaluation of Efficacy, Safety and Tolerability of Aldafermin in a Phase 2b, Randomized, Double-blind, Placebo-controlled, Multi-center

    Categories: Amino Acids, Peptides, and Proteins, Intercellular Signaling Peptides and Proteins
  10. Drug

    Spaglumic acid

    go.drugbank.com/drugs/DB08835
    Investigational

    Specifically spaglumic acid is approved in Portugal under the brand name Naabak and in Greece under the brand name Naaxia for use in patients with allergic conjunctivitis.

    Categories: Decongestants and Antiallergics