Spaglumic acid is the β-aspartyl isoform of N-Acetyl-l-aspartylglutamate, a naturally occurring neurotransmitter, used in allergic eye conditions due to its ability to stabilize mast cells. In eye drops, spaglumic acid is either a magnesium or sodium salt of N-Acetyl-l-aspartylglutamate.
- Mechanism
- Curator reviewed
Spaglumic acid is a mast cell stabilizer. Mast cells are involved in producing an allergic response by releasing inflammatory mediators such as histamine. Mast cell stablizers block the release of histamine and other mediators by inhibiting mast cell degranulation, which is the process of releasing these mediators. Inhibition occurs through inhibition of specific calcium channels to stabilize the mast cell and prevent degranulation.
- Primary indication
- Used in patients with allergic conjunctivitis.Curator reviewed · 3 structured indications
- Formula / weight
- C11H16N2O8 · 304.255 g/mol (avg)
Resolves to
GUCKKCMJTSNWCU-BQBZGAKWSA-NSMILESCC(=O)N[C@@H](CC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(O)=OWhat you can answer from here — as of March 06, 2025
Which drugs share a target with Spaglumic acid, and which of those have an active Phase 3 trial?
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