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Andexanet alfa
go.drugbank.com/drugs/DB14562ApprovedIts pharmacokinetic properties are not reported to be affected by factor Xa inhibitors [A35518]. … Andexanet alfa retains the structural similarity to that of endogenous human factor Xa, but exists in its mature functional form without the need for activation via the intrinsic or extrinsic coagulation
Zotepine
go.drugbank.com/drugs/DB09225ApprovedWithdrawn[L1082] When the analysis of antipsychotics was retaken in 2016 by the FDA, zotepine did not reach the threshold effect to be further studied.[L1313]. … It was designed and synthesized by Fujisawa Pharmaceutical Co Ltd.[A31855] It has been used as an antipsychotic in Japan, India and some places in Europe like UK and Germany since 1980's.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeChromium
go.drugbank.com/drugs/DB11136ApprovedInvestigationalAccording to the National Institute of Health, the daily dietary reference intake (DRI) of chromium for adult male and non-pregnant female are 35 μg and 25 μg, respectively [L1986]. … in commercial settings and are known to be human carcinogens [L1982].
Mixtures: Doctor's Choice Brand for Men, ADDAMEL NCasirivimab
go.drugbank.com/drugs/DB15941ApprovedInvestigationalCasirivimab and imdevimab are investigational recombinant human IgG1 monoclonal antibodies that, at this time, are not officially approved by the FDA. … [L23524] In November 2021, the same indication was approved by the EMA.
Leucovorin
go.drugbank.com/drugs/DB00650ApprovedInvestigational[L56092, A257419] Unlike folic acid, leucovorin does not require the enzyme dihydrofolate reductase (DHFR) for activation, allowing it to function even when DHFR is inhibited by drugs like methotrexate … anemias resulting from folate deficiency when oral therapy is not feasible.
Synonyms: N5-Formyltetrahydrofolic acid, N5-Formyl-5,6,7,8-tetrahydrofolic acidMixtures: NEO CROMATON BICOMPLESSONimodipine
go.drugbank.com/drugs/DB00393ApprovedInvestigationalIt acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. … By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction.
Fenoprofen
go.drugbank.com/drugs/DB00573ApprovedAn anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.
Categories: Anti-Inflammatory Agents, Non-Steroidal (Non-Selective), Analgesics, Non-NarcoticEthinylestradiol
go.drugbank.com/drugs/DB00977ApprovedInvestigationalEthinylestradiol was first synthesized in 1938 by Hans Herloff Inhoffen and Walter Hohlweg at Schering.[A191107] It was developed in an effort to create an estrogen with greater oral bioavailability. … [A191107] Ethinylestradiol was granted FDA approval on 25 June 1943.[L11884]
Mixtures: Lo/Ovral, Lo-ovral-28Lemborexant
go.drugbank.com/drugs/DB11951ApprovedInvestigational[L10863] Recent research in the field of sleep disorders has revealed that insomnia is likely driven not by the inability of the brain to "switch on" sleep-related circuits, but rather an inability to … Lemborexant is a novel dual orexin receptor antagonist used in the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance.
Loxoprofen
go.drugbank.com/drugs/DB09212ApprovedInvestigationalLoxoprofen is a propionic acid derivative non-steroidal anti-inflammatory drug. … It is marketed under the trade name Loxonin in Brazil, Mexico and Japan by Sankyo, as Loxomac in India, and as Oxeno in Argentina.
Categories: Analgesics, Non-Narcotic, Non COX-2 selective NSAIDS