Zotepine, with the formula (2-chloro-11-(2-dimethyl-amino-ethoxy)-dibenzo thiepin, is a neuroleptic drug. It was designed and synthesized by Fujisawa Pharmaceutical Co Ltd. It has been used as an antipsychotic in Japan, India... It has been used as an antipsychotic in Japan, India and some places in Europe like UK and Germany since 1980's.
- Mechanism
- Curator reviewed · 1 reference
Zotepine is a dopamine antagonist that has a high affinity for D1- and D2-like receptors. It presents a strong antagonism for several serotonin receptors, such as 5-HT2a, 5-HT2c, 5-HT6 and 5-HT7. Zotepine activities are also related to the inhibition of noradrenaline reuptake and serotonergic activity. All these effects allow zotepine to improve the negative and cognitive symptoms of schizophrenia.
- Primary indication
- Zotepine, like other atypical antipsychotics, is considered as the first-line treatment in newly diagnosed schizophrenia.Curator reviewed
- Formula / weight
- C18H18ClNOS · 331.86 g/mol (avg)
Resolves to
HDOZVRUNCMBHFH-UHFFFAOYSA-NSMILESCN(C)CCOC1=CC2=CC=CC=C2SC2=CC=C(Cl)C=C12What you can answer from here — as of March 06, 2025
Which drugs share a target with Zotepine, and which of those have an active Phase 3 trial?
Create a free account or log in to explore the full data card.
Create Account