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Displaying results 621 - 630 of 10000 in total
  1. Drug

    Lesinurad

    go.drugbank.com/drugs/DB11560
    ApprovedWithdrawn

    Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout. … In August 2017, a combination oral therapy consisting of lesinurad and [DB00437] was FDA-approved under the brand name Duzallo indicated for the treatment of gout-related hyperuricemia in patients with

    Synonyms: {[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acidCategories: Urate Transporter 1 Inhibitor, Heterocyclic Compounds, 1-Ring
  2. Drug

    Vinflunine

    go.drugbank.com/drugs/DB11641
    ApprovedInvestigational

    Like other vinca agents, vinflunine is an anti-mitotic agent that induces a cell cycle arrest at the G2/M phase and promotes cell death via apoptosis [L1396]. … Having an incidence of 429,700 new cases per year worldwide, urothelial carcinoma of the bladder is one of the most common malignancies that mostly affects individuals aged 50–79 years [A32626].

    Synonyms: 4'-deoxy-20',20'-difluoro-5'-norvincaleukoblastine, 20',20'-difluoro-3',4'-dihydrovinorelbineCategories: Antineoplastic and Immunomodulating Agents, P-glycoprotein substrates with a Narrow Therapeutic Index
  3. Drug

    Felodipine

    go.drugbank.com/drugs/DB01023
    Approved

    cyclic nucleotide phosphodiesterase, and blocks calcium influx through voltage-gated T-type calcium channels. … Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b.

    Synonyms: 3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate, (±)-ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylateMixtures: DELIX DUO 5 MG/5 MG FİLM KAPLI TABLET, 30 ADET, DELIX DUO 2.5 MG/2.5 MG TABLET, 30 ADET
  4. Drug

    Suzetrigine

    go.drugbank.com/drugs/DB18927
    ApprovedInvestigational

    [A264953] On January 30, 2025, suzetrigine was approved by the FDA as a first-in-class non-opioid analgesic.[L52098] … Suzetrigine is a Na<sub>V</sub>1.8 voltage-gated sodium channel blocker with analgesic properties[A264948] Na<sub>V</sub>1.8 is abundantly expressed in peripheral sensory nerves to play a role in pain

    Synonyms: 4-[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)oxolane-2-amido]pyridine2-carboxamide, 4-[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5- dimethyl-5-(trifluoromethyl)oxolane-2- carboxamido]pyridine-2-carboxamideCategories: Heterocyclic Compounds, 1-Ring, P-glycoprotein substrates
  5. Drug

    Pyridoxine

    go.drugbank.com/drugs/DB00165
    ApprovedInvestigationalNutraceuticalVet approved

    , pyridoxal 5'-phosphate and pyridoxamine 5'-phosphate. … It's important to note that Vitamin B6 is the collective term for a group of three related compounds, pyridoxine, pyridoxal, and pyridoxamine, and their phosphorylated derivatives, pyridoxine 5'-phosphate

    Synonyms: 5-hydroxy-6-methyl-3,4-pyridinedimethanol, Vitamin B 6Mixtures: LYSOBACT 20 MG/10 MG PASTİL, 30 ADET, PRİLAM DR 10 MG/10 MG DEĞİŞTİRİLMİŞ SALIMLI TABLET, 30 ADET
  6. Drug

    5-(5-(4-(4,5-dihydro-2-oxazoly)phenoxy)pentyl)-3-methyl osoxazole

    go.drugbank.com/drugs/DB08720
    Experimental

    5-(5-(4-(4,5-dihydro-2-oxazoly)phenoxy)pentyl)-3-methyl osoxazole is a solid. This compound belongs to the phenol ethers. … These are aromatic compounds containing an ether group substituted with a benzene ring. This drug is known to target genome polyprotein.

    Synonyms: 5-(5-(4-(4,5-dihydro-2-oxazoly)phenoxy)pentyl)-3-methyl osoxazole
  7. Drug

    (3S)-N-(5-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE

    go.drugbank.com/drugs/DB07222
    Experimental

    Synonyms: (3S)-N-(5-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE
  8. Drug

    N-(4-ACETYLPHENYL)-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE

    go.drugbank.com/drugs/DB06956
    Experimental

    Synonyms: N-(4-ACETYLPHENYL)-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE
  9. Drug

    (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE

    go.drugbank.com/drugs/DB07763
    Experimental

    Synonyms: (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE
  10. Drug

    {[5-(5-nitro-2-furyl)-1,3,4-oxadiazol-2-yl]thio}acetic acid

    go.drugbank.com/drugs/DB08098
    Experimental

    These are compounds containing a furan ring which bears a nitro group. It targets the protein aldose reductase.

    Synonyms: {[5-(5-nitro-2-furyl)-1,3,4-oxadiazol-2-yl]thio}acetic acid