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Tofisopam
go.drugbank.com/drugs/DB08811InvestigationalTofisopam (marketed under brand names Emandaxin and Grandaxin) is a 2,3-benzodiazepine drug which is a benzodiazepine derivative. … The D-enantiomer ([dextofisopam]) is currently in phase II trials in the U.S. for the treatment of irritable bowel syndrome.
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 CYP3A InhibitorsNadroparin
go.drugbank.com/drugs/DB08813ApprovedInvestigationalWithdrawnIt is derived from porcine sources and has a mean molecular size of 5000 daltons. … Nadroparin is a low molecular weight heparin (LMWH) which, when bound to antithrombin III (ATIII), accelerates the inactivation of factor II and factor Xa.
Products: FRAXODI 19000 IU AXA/1 ML SC ENJEKTABL SOLUSYON 2 ENJEKTOR, FRAXIPARINE 1 MLVismodegib
go.drugbank.com/drugs/DB08828ApprovedInvestigational[A258613,A258618,L45803] It was discovered by high-throughput screening of a library of small-molecule compounds and subsequent optimization through medicinal chemistry.
Synonyms: 2-chloro-N-(4-chloro-3-pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide, Benzamide, 2-chloro-N-(4-chloro-3-(2-pyridinyl)phenyl)-4-(methylsulfonyl)-Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSpaglumic acid
go.drugbank.com/drugs/DB08835InvestigationalSpaglumic acid is the β-aspartyl isoform of N-Acetyl-l-aspartylglutamate (isospaglumic Acid is N-(N-Acetyl-l-α-aspartyl)-l-glutamic acid). … In eye drops, spaglumic acid is either a magnesium or sodium salt of N-Acetyl-l-aspartylglutamate. Spaglumic acid is a mast cell stabilizer.
Synonyms: N-Acetyl-L-β-aspartyl-L-glutamic acidProducts: NAAXIA EYEDROPS 4.9 g/100 mlDADLE
go.drugbank.com/drugs/DB08856ExperimentalA delta-selective opioid (ANALGESICS, OPIOID). It can cause transient depression of mean arterial blood pressure and heart rate.
Synonyms: H-Tyr-D-Ala-Gly-Phe-D-Leu, L-Tyrosyl-D-alanylglycyl-L-phenylalanyl-D-leucineBoceprevir
go.drugbank.com/drugs/DB08873ApprovedWithdrawnBoceprevir is an inhibitor of NS3/4A, a serine protease enzyme, encoded by HCV genotypes 1 and 4 [synthesis]. … Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV).
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: VICTRELIS ® CAPSULAS 200 MG (MOLECULA PROTEGIDA)Asparaginase Erwinia chrysanthemi
go.drugbank.com/drugs/DB08886ApprovedInvestigational[L1448] L-asparaginase was first identified in 1963,[A236344] and there are different formulations of L-asparaginase, including [Asparaginase Escherichia coli] and a pegylated form of this enzyme, [Pegaspargase … [L149] In June 2021, the recombinant form of asparaginase _Erwinia chrysanthemi_ was approved by the FDA as a component of a chemotherapy regimen to treat acute lymphoblastic leukemia and lymphoblastic
Synonyms: Erwinia L-asparaginase, L-asparaginase (Erwinia)Carfilzomib
go.drugbank.com/drugs/DB08889ApprovedInvestigationalChemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, P-glycoprotein inhibitorsProducts: KYPROLIS®, KARFIB®Teduglutide
go.drugbank.com/drugs/DB08900ApprovedInvestigationalTeduglutide is a glucagon-like peptide-2 (GLP-2) analogue. It is made up of 33 amino acids and is manufactured using a strain of Escherichia coli modified by recombinant DNA technology. … Teduglutide differs from GLP-2 by one amino acid (alanine is substituted by glycine).
Synonyms: Gly(2)-GLP-2, (Gly2)GLP-2Categories: Glucagon-like Peptide-2 (GLP-2) Agonists, GLP-2 AnalogDimethyl fumarate
go.drugbank.com/drugs/DB08908ApprovedInvestigationalIt is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated
Synonyms: (E)-But-2-enedioic acid dimethyl esterProducts: YARDIX® 240MG, TECFIDERA® 240MG