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Avoralstat
go.drugbank.com/drugs/DB12120InvestigationalAvoralstat has been used in trials studying the prevention of HAE and Hereditary Angioedema.
Nusinersen
go.drugbank.com/drugs/DB13161ApprovedInvestigationalAn antisense oligonucleotide that induces survival motor neuron (SMN) protein expression, it was approved by the U.S. … FDA in December, 2016 as Spinraza for the treatment of children and adults with spinal muscular atrophy (SMA). It is adminstrated as direct intrathecal injection.
Insulin human
go.drugbank.com/drugs/DB00030ApprovedInvestigationalto produce or synthesize the insulin needed to manage circulating blood sugar levels. … Insulin is released from the pancreas following a meal to promote the uptake of glucose from the blood into internal organs and tissues such as the liver, fat cells, and skeletal muscle.
Mixtures: Novolin Ge 30/70, Novolin Ge 30/70Products: Novolin Ge Nph, Novolin Ge TorontoV1003
go.drugbank.com/drugs/DB05046Experimentalprior to discharge from hospital and at home during their recovery period. … V1003 is an intranasal formulation of buprenorphine, an opiate analgesic, for the management of post-operative pain in hospital and home settings.
Infigratinib
go.drugbank.com/drugs/DB11886ApprovedInvestigationalWithdrawn[L34304] The FDA later announced the final withdrawal of the approval of infigratinib for this indication on May 16, 2024: This decision was based on the sponsor's request due to clinical trial recruitment … [A235174] Cholangiocarcinoma is the most common primary malignancy affecting the biliary tract and the second most common primary hepatic malignancy.
Categories: Fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors, Receptor, Fibroblast Growth Factor, Type 1, antagonists & inhibitorsTryptophan
go.drugbank.com/drugs/DB00150ApprovedInvestigationalNutraceuticalWithdrawnIt can be a precursor to niacin, albeit inefficiently, in mammals.
Mixtures: Clinimix E, Clinimix ECategories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeCasimersen
go.drugbank.com/drugs/DB14984ApprovedInvestigational[A218186] Casimersen is the most recent in a line of approved PMOs for treating DMD, including [eteplirsen] and [viltolarsen]. … However, the specific mutations, and hence the precise exon skipping, targeted by each is different.
Codeine
go.drugbank.com/drugs/DB00318ApprovedIllicitInvestigationalThe relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for increasing the ability of patients to engage in day to day activities. … Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease pain by increasing the threshold for pain without impairing consciousness or altering other sensory
Mixtures: Tl-hist CD, Tl-hist CmCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeLonafarnib
go.drugbank.com/drugs/DB06448ApprovedInvestigational[A224379, A224384, A224389, A224394, A224399] Mechanistically, HGPS is underpinned by a single heterozygous C-to-T mutation at position 1824 of the _LMNA_ gene, which results in the accumulation of an … for localization to the nuclear membrane, lonafarnib inhibits progerin accumulation and improves symptoms in HGPS patients.
Atropine
go.drugbank.com/drugs/DB00572ApprovedInvestigationalVet approved[A251660,L42815,L42825,L42835] It has a variety of therapeutic applications, including pupil dilation and the treatment of anticholinergic poisoning and symptomatic bradycardia in the absence of reversible … [A251660] Atropine is a relatively inexpensive drug and is included in the World Health Organization List of Essential Medicines.[A251675]
Mixtures: Re-PB Hyos, Re-PB HyosProducts: SULFATO DE ATROPINA 0.1 %, ATROPINE SULFAT IE AMPUL 1 MG/ML, 10 ADET