Avoralstat

DB12120InvestigationalSmall molecule

Avoralstat has been used in trials studying the prevention of HAE and Hereditary Angioedema.

Chemical structure of Avoralstat
Mechanism
Curator reviewed
Formula / weight
C28H27N5O5 · 513.554 g/mol (avg)
Also known as
3-(2-((4-Carbamimidoylphenyl)carbamoyl)-4-ethenyl-5-methoxyphenyl)-6-((cyclopropylmethyl)carbamoyl)pyridine-2-carboxylic acid · 3-[2-(4-carbamimidoyl-phenylcarbamoyl)-5-methoxy-4-vinyl-phenyl]-6-(cyclopropylmethyl-carbamoyl)-pyridine-2-carboxylic acid · 3-[2-[(4-carbamimidoylphenyl)carbamoyl]-4-ethenyl-5-methoxyphenyl]-6-(cyclopropylmethylcarbamoyl)pyridine-2-carboxylic acid
Code names
BCX-4161

Resolves to

Compound
UNIIUX17773O15CAS918407-35-9ChEMBLCHEMBL4297502PubChem86566678
Structure
InChIKeyTUWMKPVJGGWGNL-UHFFFAOYSA-NSMILESCOC1=CC(=C(C=C1C=C)C(=O)NC1=CC=C(C=C1)C(N)=N)C1=CC=C(N=C1C(O)=O)C(=O)NCC1CC1
Targets
P03952KLKB1P01042KNG1P20151KLK2

What you can answer from here — as of June 15, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action
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4Clinical trialsPhase, status and sponsor resolved per trial
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5+ReferencesStructured and connected to the statements they support
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