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Displaying results 6431 - 6440 of 10000 in total
  1. Drug

    Gumelutamide

    go.drugbank.com/drugs/DB21615
    Experimental

    Gumelutamide has a monoisotopic molecular weight of 420.15 Da. … Gumelutamide is a small molecule drug. The usage of the INN stem '-lutamide' in the name indicates that Gumelutamide is a non-steroid antiandrogen.

  2. Drug

    Frevecitinib

    go.drugbank.com/drugs/DB21681
    Investigational

    Frevecitinib has a monoisotopic molecular weight of 415.18 Da. … Frevecitinib is a small molecule drug. The usage of the INN stem '-citinib' in the name indicates that Frevecitinib is a Janus kinase inhibitor.

  3. Drug

    Odentegravir

    go.drugbank.com/drugs/DB21708
    Experimental

    Odentegravir has a monoisotopic molecular weight of 421.12 Da. … Odentegravir is a small molecule drug. The usage of the INN stem '-tegravir' in the name indicates that Odentegravir is a HIV integrase inhibitor.

  4. Drug

    Mitoquinone

    go.drugbank.com/drugs/DB05063
    Investigational

    -- where they accumulate up to a thousand fold. … In 2004, a genomic study of hereditary early-onset Parkinson's disease demonstrated a direct molecular link between mitochondrial dysfunction and the pathogenesis of Parkinson's disease.

  5. Drug

    Methacholine

    go.drugbank.com/drugs/DB06709
    Approved

    [L31763] In patients with AHR, a lower dose of methacholine is required to induce bronchoconstriction, which forms the basis for the methacholine challenge test to diagnose AHR. … [A229603, A229618, A229643] Methacholine is a non-specific cholinergic agonist (parasympathomimetic) that acts through muscarinic receptors in the lungs to induce bronchoconstriction.

  6. Drug

    QazCovid-in

    go.drugbank.com/drugs/DB16441
    Investigational

    The QazCovid-in vaccine, an inactivated vaccine, was developed and tested in the Kazakh Research Institute for Biological Safety Problems[L30628].

  7. Drug

    Devafidugene civaparvovec

    go.drugbank.com/drugs/DB16790
    Investigational

    Devafidugene civaparvovec is an investigational _in vivo_ genome editing product. … It uses proprietary zinc finger nucleases (ZFN) that insert a functional copy of the alpha-L-iduronidase (IDUA) enzyme.

  8. Drug

    NGN-401

    go.drugbank.com/drugs/DB18594
    Investigational

    NGN-401 is a recombinant serotype 9 adeno-associated virus (AAV) encoding an intron encoding a miRNA generating sequence, complementary miRNA binding sites and a full-length human methyl cytosine binding

    Synonyms: Recombinant serotype 9 adeno-associated virus (AAV) encoding an intron encoding a miRNA generating sequence, complementary miRNA binding sites and a full-length human methyl cytosine binding protein 2
  9. Drug

    Cimetropium

    go.drugbank.com/drugs/DB09271
    Investigational

    Cimetropium is a semi-synthetic belladonna alkaloid and derivative of scopolamine. It is a potent antimuscarinic and an effective antispasmodic drug. … It is also endowed of a direct myolitic action which partially accounts for its antispasmodic activity. It has never been approved for use in the U.S. or Canada.

  10. Drug

    AZD2389

    go.drugbank.com/drugs/DB22104
    Investigational

    NCT06973005: A Study to Investigate How Multiple Oral Doses of AZD2389 Affect the Pharmacokinetics of Midazolam, Caffeine, and Bupropion in Healthy Participants). … AZD2389 is an investigational small molecule inhibitor of fibroblast activation protein (FAP).[L54978] It is currently undergoing safety, tolerability, and PK/PD profiling in clinical trials (e.g.