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Opium
go.drugbank.com/drugs/DB11130ApprovedIllicitIt has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. … [L1762] Opium has gradually been superseded by a variety of synthetic opioids and general anesthetics.
Mixtures: Donnagel-PG Liq, Donnagel-PG CapCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesBarth Syndrome
go.drugbank.com/conditions/DBCOND0000526Drugs: ElamipretideSynonyms: 3-Methylglutaconic aciduria type 2 (disorder)Stage 4 Pancreatic adenocarcinoma
go.drugbank.com/conditions/DBCOND0025282Drugs: GemcitabineSynonyms: Stage 4 Pancreatic adenocarcinomaEnfuvirtide
go.drugbank.com/drugs/DB00109ApprovedInvestigationalEnfuvirtide is a 36 amino acid biomimetic peptide that is structurally similar to the HIV proteins that are responsible for the fusion of the virus to cell membranes and subsequent intracellular uptake … The first agent in the novel class of antiretroviral drugs called HIV fusion inhibitors, enfuvirtide works by inhibiting HIV-1 fusion with CD4 cells.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2E1 SubstratesProducts: FUZEON POLVO SOLUCION INYECTABLE 90 MG/MIAbrocitinib
go.drugbank.com/drugs/DB14973ApprovedInvestigationalAbrocitinib is an oral small-molecule inhibitor of Janus kinase 1 (JAK1). … [L39774] The Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signalling pathway plays a central role in the pathogenesis of a variety of autoimmune and inflammatory diseases,
Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsProducts: CIBINQO® 50 MG, CIBINQO® 200 MGMilnacipran
go.drugbank.com/drugs/DB04896ApprovedInvestigational(BACE-1), which has investigationally been associated with β-amyloid plaque formation - making the agent a possible course of treatment for Alzheimer's disease [A175957]. … Nevertheless, milnacipran demonstrates a somewhat unique characteristic among SNRIs to elicit a relatively balanced reuptake inhibition of both serotonin and noradrenaline, with a somewhat increased preference
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsProducts: IXEL 25 MG KAPSUL, 28 ADET, Ixel 25 mg - KapselnUlipristal
go.drugbank.com/drugs/DB08867ApprovedInvestigationalA recent systematic review proclaimed that the majority of available evidence demonstrates an inhibitory effect on ovulation rather than a post-fertilization effect on the endometrium, which has been heavily … It is a derivative of 19-norprogesterone and has both antagonistic and partial agonist activity at the progesterone receptor.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: ESMYA® 5 MG COMPRIMIDOS, JOSEİ 30 MG TABLET, 1 ADETGemifloxacin
go.drugbank.com/drugs/DB01155ApprovedInvestigationalGemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia.
Categories: 4-Quinolones, Heterocyclic Compounds, 2-RingProducts: ONFACT 320 MG FİLM TABLET, 5 ADET, ONFACT 320 MG FİLM TABLET, 7 ADETAnastrozole
go.drugbank.com/drugs/DB01217ApprovedInvestigational[L8863] Anastrozole is also related to [exemestane], a steroidal AI, but its non-steroidal nature provides stark advantages including a lack of steroid-associated adverse effects such as weight gain and … Anastrozole is a non-steroidal aromatase inhibitor (AI), similar to [letrozole], used to decrease circulating estrogen levels in the treatment of postmenopausal women with estrogen-responsive breast cancer
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: α,α,α',α'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrileAtazanavir
go.drugbank.com/drugs/DB01072ApprovedInvestigationalFood and Drug Administration (FDA) approved atazanavir on June 20, 2003.
Mixtures: ANCEF ® R, ANCEF ® RCategories: P-glycoprotein inducers, P-glycoprotein inhibitors