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Ephedrine
go.drugbank.com/drugs/DB01364ApprovedInvestigational[L12972] Ephedrine and [phenylephrine] are still used to treat hypotension, but their use in other indications has decreased due to the development of more selective adrenergic agonists. … It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepinephrine from sympathetic neurons, inhibiting norepinephrine reuptake and displacing more norepinephrine
Categories: Epinephrine and similars, Herbs and Natural ProductsProducts: Ephedrine HCl - Tab 25mg, Ephedrine Hydrochloride Tablets 25mgSecukinumab
go.drugbank.com/drugs/DB09029ApprovedInvestigational[A249840] Following its first global approval in Japan in December 2014, secukinumab was approved by the European Commission on January 15, 2015, and by the FDA a few days after (January 21, 2015). … [A249805] It is currently approved to treat a number of chronic inflammatory conditions, such as plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and hidradenitis suppurativa.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: COSENTYX SOLUTION FOR INJECTION IN PREFILLED SYRINGE 75MG/0.5ML, COSENTYX SOLUTION FOR INJECTION IN PREFILLED SYRINGE 150MG/MLBenzatropine
go.drugbank.com/drugs/DB00245ApprovedInvestigational[A37914] Benztropine was developed by USL Pharma and officially approved by the FDA on 1996.[L5500] … The generation of structure-activity relationships proved that benztropine derivatives with the presence of a chlorine substituent in the para position in one of the phenyl rings produces an increased
Products: Cogentin Inj 1mg/ml, TICOLIN 2 MG/2 ML IM/IV ENJEKSIYONLUK ÇÖZELTI IÇEREN AMPUL,1 ADETIsopropyl alcohol
go.drugbank.com/drugs/DB02325ApprovedInvestigationalAn isomer of 1-propanol. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.
Mixtures: Bus and Classroom Yellow, Care Bus and Classroom YellowCategories: Antiseptics and Disinfectants, Compounds used in a research, industrial, or household settingVerapamil
go.drugbank.com/drugs/DB00661ApprovedInvestigational[A188514] It is a member of the non-dihydropyridine class of calcium channel blockers, which includes drugs like [diltiazem] and [flunarizine], but is chemically unrelated to other cardioactive medications … greater potency than the R-enantiomer, but is metabolized at a higher rate.
Mixtures: TARKA 180MG/2MG, TARKA 180MG/2MGCategories: Verapamil and analogues, trandolapril and verapamilCapecitabine
go.drugbank.com/drugs/DB01101ApprovedInvestigationalCapecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. … Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.
Categories: Fluorouracil and prodrugs, Antineoplastic and Immunomodulating AgentsProducts: Capecitabine 500mg, XELODA 500MGAcarbose
go.drugbank.com/drugs/DB00284ApprovedInvestigational[L31633,A37868] By inhibiting the activity of these enzymes, acarbose limits the absorption of dietary carbohydrates and the subsequent postprandial increase in blood glucose and insulin levels. … Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines.
Categories: Drugs Used in Diabetes, metformin and acarboseProducts: GLUCOBAY TABLET 100MG, Gacose Tablet 100mgSarilumab
go.drugbank.com/drugs/DB11767ApprovedInvestigational[A27262] Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approved in May 2017 and followed by EU approval in June 2017 for the treatment of moderate to severe rheumatoid … [A27265] RA is a chronic inflammatory disease characterized by polyarthritis, and its treatment has been challenged by the different responses in every patient.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: KEVZARA SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 150MG, KEVZARA Solution for Injection in Pre-filled Pen 150mgAbiraterone
go.drugbank.com/drugs/DB05812ApprovedInvestigational[L54773,L54768] As abiraterone has poor oral bioavailability and is susceptible to hydrolysis by esterases, abiraterone acetate was developed as an orally bioavailable prodrug with enhanced stability … Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis
Categories: niraparib and abiraterone, abiraterone and corticosteroidsProducts: XBIRA® 500MG, ZYTIGA FILM-COATED TABLET 500MGAcitretin
go.drugbank.com/drugs/DB00459ApprovedInvestigationalAn oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate.
Categories: Skin and Mucous Membrane AgentsProducts: NOVATRETIN CAPSULE 10MG, Novatretin 10mg Capsules