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Displaying results 651 - 660 of 10000 in total
  1. Drug

    Riociguat

    go.drugbank.com/drugs/DB08931
    ApprovedInvestigational

    Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for … Riociguat is marketed under the brand Adempas® by Bayer HealthCare Pharmaceuticals. Treatment with riociguat costs USD $7,500 for 30 days of treatment.

    Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: Methyl N-[4,6-Diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methyl-carbaminate
  2. Drug

    N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE

    go.drugbank.com/drugs/DB07334
    Experimental

    Synonyms: N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE
  3. Drug

    N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-4-biphenylcarboxamide

    go.drugbank.com/drugs/DB07833
    Experimental

    Synonyms: N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-4-biphenylcarboxamide
  4. Drug

    Lazertinib

    go.drugbank.com/drugs/DB16216
    ApprovedInvestigational

    [A264289] It was approved by the FDA on August 19, 2024.[L51189] Lazertinib is used alone or in combination with other chemotherapeutic agents.[L51184] … [A264299, A264304] Lazertinib was first approved in South Korea on January 18, 2021, for the treatment of _EGFR_ T790M mutation-positive non-small cell lung cancer (NSCLC) with EGFR mutations.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsSynonyms: 2-PROPENAMIDE, N-(5-((4-(4-((DIMETHYLAMINO)METHYL)-3-PHENYL-1H-PYRAZOL-1-YL)-2-PYRIMIDINYL)AMINO)-4-METHOXY-2-(4-MORPHOLINYL)PHENYL)-, N-(5-((4-(4-((DIMETHYLAMINO)METHYL)-3-PHENYL-1H-PYRAZOL-1-YL)PYRIMIDIN-2-YL)AMINO)-4-METHOXY-2-MORPHOLINOPHENYL)ACRYLAMIDE
  5. Drug

    (5Z)-5-[(5-ethylfuran-2-yl)methylidene]-2-[[(S)-(4-fluorophenyl)-(2H-tetrazol-5-yl)methyl]amino]-1,3-thiazol-4-one

    go.drugbank.com/drugs/DB08710
    Experimental

    Synonyms: (5Z)-5-[(5-ethylfuran-2-yl)methylidene]-2-[[(S)-(4-fluorophenyl)-(2H-tetrazol-5-yl)methyl]amino]-1,3-thiazol-4-one
  6. Drug

    Linperlisib

    go.drugbank.com/drugs/DB17235
    Investigational

    Synonyms: -in-2, N-(5-(6-fluoro-8-((4-(2-hydroxypropan-2-yl) piperidin-1-yl)methyl)-2-morpholinoquinazolin-4-yl)-2-methoxypyridin-3-)methanesulfonamide
  7. Drug

    Nefazodone

    go.drugbank.com/drugs/DB01149
    ApprovedWithdrawn

    Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or even death, with the incidence of severe liver damage was shown to be approximately 1 in 250,000 to … Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury.

    Synonyms: 1-(3-(4-(m-Chlorophenyl)-1-piperazinyl)propyl)-3-ethyl-4-(2-phenoxyethyl)-delta2-1,2,4-triazolin-5-oneCategories: Serotonin 5-HT1 Receptor Antagonists, Serotonin 5-HT2 Receptor Antagonists
  8. Drug

    ODM-207

    go.drugbank.com/drugs/DB18820
    Investigational

    Synonyms: BET-IN-4, 2(1H)-Quinolinone, 6-(3,5-dimethyl-4-isoxazolyl)-7-methoxy-3-methyl-1-(2-pyridinylmethyl)-Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring
  9. Drug

    Orotidylic acid

    go.drugbank.com/drugs/DB02957
    Experimental

    Synonyms: 6-carboxy-5'-uridylic acid, Orotidine 5'-phosphateCategories: Heterocyclic Compounds, 1-Ring
  10. Drug

    Methoxsalen

    go.drugbank.com/drugs/DB00553
    ApprovedInvestigational

    It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. … A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia.

    Synonyms: 8-MP, 8-methoxy-4',5':6,7-furocoumarinCategories: Compounds used in a research, industrial, or household setting, Heterocyclic Compounds, 1-Ring