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Methoxsalen is a furocoumarin used to treat psoriasis and vitiligo. A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia.
- Mechanism
- Curator reviewed
After activation it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.
- Primary indication
- For the treatment of psoriasis and vitiligoCurator reviewed · 5 structured indications
- Formula / weight
- C12H8O4 · 216.192 g/mol (avg)
- First approval
- Canada, 2004 · United States, 1954
- Also known as
- 8-Methoxyfuranocoumarin · 8-methoxypsoralen · 8-MOP · 8-MP · Ammoidin
- Code names
- NSC-45923
- Brand names
- Oxsoralen
- Uvadex
Resolves to
Clinical / RWD
Structure
InChIKey
QXKHYNVANLEOEG-UHFFFAOYSA-NSMILESCOC1=C2OC(=O)C=CC2=CC2=C1OC=C2Targets
What you can answer from here — as of September 23, 2026
2Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
Which drugs share a target with Methoxsalen, and which of those have an active Phase 3 trial?