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Osimertinib
go.drugbank.com/drugs/DB09330ApprovedInvestigationaltesting and which has progressed following therapy with a first-generation EGFR tyrosine kinase inhibitor. … In contrast, third-generation inhibitors are specific for the gate-keeper T790M mutations which increases ATP binding activity to EGFR and result in poor prognosis for late-stage disease.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamideSimvastatin
go.drugbank.com/drugs/DB00641ApprovedInvestigational[A181087, A181406] Simvastatin and other drugs from the statin class of medications including [atorvastatin], [pravastatin], [rosuvastatin], [fluvastatin], and [lovastatin] are considered first-line … were found in clinical studies to result in a 45.8% to 54.6% decrease in LDL cholesterol levels, while simvastatin has been found to have an average decrease in LDL-C of ~35%.
Mixtures: EZETIMIBE E SIMVASTATINA EG, EZETIMIBE E SIMVASTATINA EGProducts: SIMVASTATINA EG, SIMVASTATIN AL 5MGCeftriaxone
go.drugbank.com/drugs/DB01212ApprovedInvestigationalCeftriaxone is a broad-spectrum third-generation cephalosporin antibiotic. … [A215582] It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges[A215582], eyes[A215647], and inner ear[A215627].
Products: CEFTRIAXONE EG, ROCEPHIN 1 GR IM ENJ. COZ. HAZ. ICIN TOZ ICEREN FLAKONDinutuximab
go.drugbank.com/drugs/DB09077ApprovedInvestigationalneuroblastoma who achieve at least a partial response to prior first-line multiagent, multimodality therapy. … Despite a high clinical response seen after first-line treatment, the complete eradication of neuroblastoma is rarely achieved and the majority of patients with advanced disease suffer a relapse.
Amoxicillin
go.drugbank.com/drugs/DB01060ApprovedInvestigationalVet approvedAmoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. … [A190648] Amoxicillin was granted FDA approval on 18 January 1974.[L11644]
Mixtures: AMOXICILLINA E ACIDO CLAVULANICO ZENTIVA LAB, AMOXICILLINA E ACIDO CLAVULANICO SANDOZ A/SProducts: ES-MOXI 50% Granules, AMOXICILLINA EGSildenafil
go.drugbank.com/drugs/DB00203ApprovedInvestigationalRegardless, sildenafil, among a variety of other similar or related PDE5 inhibitors, has become a common and effective treatment for erectile dysfunction and since its formal approval for medical use in … in some countries [L5656].
Categories: Drugs Used in Erectile DysfunctionProducts: SILDENAFIL EG, SILDENAFIL EG STADA ITALIALidocaine
go.drugbank.com/drugs/DB00281ApprovedInvestigationalVet approvedRegardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. … In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety
Mixtures: De La Cruz Mercurochrome, Holy Water Mercy In A BottleSynonyms: 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamideIbandronate
go.drugbank.com/drugs/DB00710ApprovedInvestigational[L13805,L13808] Ibandronate was first described in the literature in 1993 as a treatment for bone loss in dogs.[A203138] Ibandronate was granted FDA approval on 16 May 2003.[L13805] … Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to [zoledronic acid], [minodronic acid], and [risedronic acid].
Products: ACIDO IBANDRONICO EG, BONVIVA 3MG/3ML ILO IN FERSodium fluoride
go.drugbank.com/drugs/DB09325ApprovedInvestigationalNow, sodium fluoride may be found in a variety of gels, varnishes, rinses, toothpaste products, and fluoride treatments provided in dental care. … Sodium fluoride is an inorganic chemical compound that is a source of the fluoride ion in many applications, including dental care and radiographic imaging when it is used as [Fluoride ion F-18].
Mixtures: PREVENT 2 EN 1, E-Z CupsCategories: Compounds used in a research, industrial, or household settingTrimetazidine
go.drugbank.com/drugs/DB09069ApprovedInvestigationalTrimetazidine is a piperazine derivative indicated for the symptomatic treatment of stable angina pectoris in patients inadequately controlled or intolerant to first line therapies. … However, it has been approved in France since 1978.[L33020]