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Vismodegib
go.drugbank.com/drugs/DB08828ApprovedInvestigationalThe Hedgehog signaling pathway plays an important role in the development of organs and tissues during embryogenesis. … Vismodegib is an orally active small molecule that inhibits the hedgehog signaling pathway by binding to and inhibiting the transmembrane protein smoothened homologue (SMO).
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C19 InhibitorsProducts: Erigib 150 mg Sert Kapsül, 28 ADET, ERIVEDGE 150 MG SERT KAPSÜL ,28 KAPSÜLMizolastine
go.drugbank.com/drugs/DB12523ApprovedMizolastine is under investigation in clinical trial NCT01928316 (A Bioequivalence Study of Domestic (Made in China) and Imported Mizolastine Tablets in Healthy Volunteers).
Categories: Cytochrome P-450 CYP2D6 Inhibitors, Cytochrome P-450 Enzyme InhibitorsProducts: MIZOLEN 10 MG TABLETAS DE LIBERACION PROLONGADADenosumab
go.drugbank.com/drugs/DB06643ApprovedInvestigationalJubbonti® (denosumab-bbdz)[L53058]—were approved by the FDA in March 2024 for all indications of the reference products Xgeva® and Prolia®; Both biosimilars also received marketing authorization in the EU … It further received additional indication approval to increase bone mass in men at high risk for fracture receiving androgen deprivation therapy for non-metastatic prostate cancer and women at high risk
Products: XGEVA® 120 MG/1.7 ML, XGEVA Solution for Injection 120 mg/vialFlucloxacillin
go.drugbank.com/drugs/DB00301ApprovedInvestigationalWithdrawnAntibiotic analog of cloxacillin.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersProducts: FLOKSIN 250 MG SURUP HAZIRLAMAK ICIN TOZ, 150 ML, PENFLOKS 250 MG/5 ML ŞURUP HAZIRLAMAK İÇİN KURU TOZ, 150 MLMegestrol acetate
go.drugbank.com/drugs/DB00351ApprovedInvestigationalVet approvedA progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: MGACetuximab
go.drugbank.com/drugs/DB00002ApprovedInvestigational[A227963] EGFR is often mutated in certain types of cancer and serves as a driver of tumorigenesis. … Cetuximab is a recombinant chimeric human/mouse IgG1 monoclonal antibody that competitively binds to epidermal growth factor receptor (EGFR) and competitively inhibits the binding of epidermal growth factor
Products: ERBITUX 100 MG/20 ML IV INFUZYON ICIN COZELTI ICEREN FLAKON, 1 ADET, ERBITUX 500 MG/100 ML IV INFUZYON ICIN COZELTI ICEREN FLAKON, 1 ADETFondaparinux
go.drugbank.com/drugs/DB00569ApprovedInvestigationalFondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. … thromboembolism in patients who have undergone orthopedic surgery of the lower limbs (e.g. hip fracture, hip replacement and knee surgery); to prevent VTE in patients undergoing abdominal surgery who are are at
Products: ARIXTRA 10 MG/0.8 ML S.C. ENJEKSIYONLUK COZELTI ICEREN KULLANIMA HAZIR SIRINGA, 10 ADET, ARIXTRA 2.5 MG/0.5 ML ENJEKSIYONLUK SOL.10 KUL.HAZ.SIRINGASilodosin
go.drugbank.com/drugs/DB06207ApprovedInvestigationalSilodosin is available as oral capsules with common trade names Rapaflo and Urorec. It is indicated for the symptomatic treatment of benign prostatic hyperplasia in adults. … Silodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α<sub>1A</sub> subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: SILODOSIN AL 4 MG HKP, SILODOSIN AL 8 MG HKPPalivizumab
go.drugbank.com/drugs/DB00110ApprovedInvestigationalHumanized monoclonal antibody (IgG1k) produced by recombinant DNA technology, directed to an epitope in the A antigenic site of the F protein of respiratory syncytial virus (RSV). … Synagis is a composite of human (95%) and murine (5%) antibody sequences.
Products: SYNAGIS® 50 MG, SYNAGIS®100 MG SOLUCION PARA INYECCIÓNIsosorbide mononitrate
go.drugbank.com/drugs/DB01020ApprovedInvestigational[L11743] Isosorbide mononitrate has a longer duration of action than [nitroglycerin] due to its slow onset of absorption and metabolism. … Isosorbide mononitrate is an organic nitrate with vasodilating properties.
Synonyms: Mononitrato de isosorbida, IS 5-MNProducts: ISMN AL 100 RETARD, ISMN AL 50 RETARD