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Displaying results 6691 - 6700 of 10000 in total
  1. Drug

    N,N,N-trimethylglycinium

    go.drugbank.com/drugs/DB04455
    Investigational

    A naturally occurring compound that has been of interest for its role in osmoregulation. … Betaine has also been used in the treatment of liver disorders, for hyperkalemia, for homocystinuria, and for gastrointestinal disturbances. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1341)

    Synonyms: N,N,N-trimethylglycinium
  2. Drug

    AAV1-FS344

    go.drugbank.com/drugs/DB17855
    Investigational

    It is being investigated for the treatment of Duchenne Muscular Dystrophy, Becker Muscular Dystrophy, and inclusion body myositis.[L46742, L46747, L46752] … AAV1-FS344 is an investigational gene therapy developed by Milo Biotechnology to deliver follistatin, a potent myostatin inhibitor.

  3. Drug

    SYNB1020

    go.drugbank.com/drugs/DB17667
    Investigational

    It was initially designed to convert ammonia to L-arginine [A258838] and granted orphan designation by the FDA for the treatment of urea cycle disorders in August 2016;[L45988] however, the manufacturer … discontinued further development of SYNB1020 to treat hyperammonemia due to a lack of evidence of ammonia-lowering activities by SYNB1020 in a Phase 1b/2a study.

  4. Drug

    Tribenoside

    go.drugbank.com/drugs/DB13227
    Investigational

    Anti-inflammatory agent used in edema of extremities, varicose veins & phlebitis.

    Categories: Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use, Analgesics, Non-Narcotic
  5. Drug

    Imazodan

    go.drugbank.com/drugs/DB20144
    Experimental

    Imazodan is a small molecule drug. The usage of the INN stem '-dan' in the name indicates that Imazodan is a cardiac stimulant, pimobendan derivative.

    Categories: Compounds used in a research, industrial, or household setting
  6. Drug

    HNM01

    go.drugbank.com/drugs/DB06531
    Experimental

    It entered Phase 1 clinical trials for the treatment of HIV infections but was discontinued during this phase … The drug hNM01, a humanized monoclonal antibody developed by SRD Pharmaceuticals, Inc., targets the V(3) region of the HIV-1 envelope protein gp120, functioning as an HIV replication inhibitor.

  7. Drug

    SPP 301

    go.drugbank.com/drugs/DB05290
    Investigational

    SPP301 (Avosentan) is a potent and highly selective ET[A] receptor blocker and is clinically investigated in diabetic nephropathy. … This study was designed to evaluate whether avosentan influences the pharmacokinetics of steroid oral contraceptives.

  8. Drug

    Radotermin

    go.drugbank.com/drugs/DB19127
    Investigational

    Radotermin is under investigation in clinical trial NCT01182337 (A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal Rhgdf-5 for the

  9. Drug

    Frespaciguat

    go.drugbank.com/drugs/DB21683
    Investigational

    Frespaciguat is under investigation in clinical trial NCT05612035 (Frespaciguat (MK-5475) INSIGNIA-PH-COPD: A Study of the Efficacy and Safety of Frespaciguat (an Inhaled sGC Stimulator) in Adults With … Frespaciguat is a small molecule drug. The usage of the INN stem '-ciguat' in the name indicates that Frespaciguat is a guanylate cyclase activator and stimulator.

  10. Target

    Folate receptor alpha

    go.drugbank.com/bio_entities/BE0003405
    TargetTransporterHumans

    Required for normal embryonic development and normal cell proliferation (By similarity) … Has high affinity for folate and folic acid analogs at neutral pH (PubMed:23851396, PubMed:23934049, PubMed:2527252, PubMed:8033114, PubMed:8567728).

    Synonyms: FOLR