Folate receptor alpha

BE0003405ProteinHumansFOLR1

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells (PubMed:19074442, PubMed:23851396, PubMed:23934049, PubMed:2527252, PubMed:8033114, PubMed:8567728). It is acted on by 16 drugs in DrugBank.

Gene name
FOLR1
UniProtKB entry
P15328Swiss-Prot
Cellular location
Cell membrane
Residues / weight
257 residues · 29,819 Da
Also known as
Adult folate-binding protein · FBP · Folate receptor 1 · Folate receptor, adult · FOLR

Resolves to

Protein
UniProtP15328UniProt nameFOLR1_HUMAN
Gene
HGNCHGNC:3791NCBI Gene2348GeneCardsFOLR1
Pharmacology
IUPHAR/GtoPdb3212KEGGhsa:2348
Structure
PDB4KM6PDB4KM7PDB4KMX
Drugs

What you can answer from here — as of September 07, 2019

16DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
16Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
6GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
63+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Folate receptor alpha, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In