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Human thrombin
go.drugbank.com/drugs/DB11571ApprovedInvestigationalHuman thrombin is a sterile solution, pH 6.8-7.2, containing highly purified human thrombin for the activation of clotting. … In particular, while human thrombin products are made from pooled human source plasma, recombinant thrombin is a human coagulation protein produced via recombinant DNA technology from a genetically modified
Pibrentasvir
go.drugbank.com/drugs/DB13878ApprovedInvestigationalPibrentasvir is available as an oral combination therapy with [DB13879] under the brand name Mavyret. … Individual NS5A amino acid substitutions that reduced susceptibility to pibrentasvir include M28G or Q30D in a genotype 1a replicon and P32-deletion in a genotype 1b replicon [L940].
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesCitric acid
go.drugbank.com/drugs/DB04272ApprovedInvestigationalNutraceuticalVet approvedA key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium-chelating ability. … [L14120] It is also used in combination with magnesium oxide to form magnesium citrate, an osmotic laxative.[L43832]
Mixtures: Av-1000, Acd-ACategories: Compounds used in a research, industrial, or household settingMethyl salicylate
go.drugbank.com/drugs/DB09543ApprovedInvestigationalVet approvedIt is used as a flavoring agent in chewing gums and mints in small concentrations and added as antiseptic in mouthwash solutions. … It can be manufactured synthetically and it used as a fragrance, in foods, beverages, and liniments.
Mixtures: Pain Relieving Po Tong Oil, Refined Gou Pi Pain Relieving PlasterCategories: Compounds used in a research, industrial, or household settingGlecaprevir
go.drugbank.com/drugs/DB13879ApprovedInvestigationalGlecaprevir is available as an oral combination therapy with [DB13878] under the brand name Mavyret. … It demonstrates a high genetic barrier against resistance mutations of the virus.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesChlorthalidone
go.drugbank.com/drugs/DB00310ApprovedInvestigationalChlorthalidone has been shown to have a number of pleiotropic effects that differentiate it from other diuretics such as [DB00999]. … Chlorthalidone is a thiazide-like diuretic used for the treatment of hypertension and for management of edema caused by conditions such as heart failure or renal impairment.
Mixtures: Aa-atenidone, Aa-atenidoneVecabrutinib
go.drugbank.com/drugs/DB16657InvestigationalVecabrutinib is under investigation in clinical trial NCT03037645 (Safety, PK, PD, and Antitumor Activity of Vecabrutinib (SNS-062) in B Lymphoid Cancers).
Eucalyptus oil
go.drugbank.com/drugs/DB11114ApprovedEucalyptus oil is a distilled oil derived from the leaves of the tree Eucalyptus.
Mixtures: Vaporizing Chest Rub 4 oz. 3 pk, UNGUENTO AL MENTOL BLEMOXEnfortumab vedotin
go.drugbank.com/drugs/DB13007ApprovedInvestigational[L10836] It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protease-cleavable … Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesUndecylenic acid
go.drugbank.com/drugs/DB11117ApprovedDue to its bifunctional properties, undecylenate is also used as a linking molecule to conjugate other biomolecules such as proteins. It serves as an acid moiety for anabolic steroid boldenone. … It is used as a precursor in the manufacture of aromatic chemicals, polymers or modified silicones [L1891].
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