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Venlafaxine
go.drugbank.com/drugs/DB00285ApprovedInvestigationalVenlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). … It was also considered a second-line treatment for obsessive-compulsive disorder (OCD).
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: VENOXOR®75 MG, M-venlafaxine XRAtomoxetine
go.drugbank.com/drugs/DB00289ApprovedInvestigationalMany contain a blackbox warning stating that CNS stimulants, including methylphenidate-containing products and amphetamines, have a high potential for abuse and dependence. … More recently, positron emission tomography (PET) imaging studies in rhesus monkeys have shown that atomoxetine also binds to the serotonin transporter (SERT),[A178111] and blocks the N-methyl-d-aspartate
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesProducts: STRATTERA® 80 MG, ATTENTHO®25 MG CAPSULASBupivacaine
go.drugbank.com/drugs/DB00297ApprovedInvestigationalBupivacaine is a widely used local anesthetic agent.
Synonyms: 1-Butyl-2',6'-pipecoloxylidide, dl-1-Butyl-2',6'-pipecoloxylidideMixtures: Mlp A-2, Mlp A-1Penciclovir
go.drugbank.com/drugs/DB00299ApprovedDisplaying low toxicity and good selectivity, penciclovir is a nucleoside analogue. … Penciclovir is a synthetic acyclic guanine derivative with antiviral activity used for the treatment of various herpes simplex virus (HSV) infections.
Synonyms: 9-(4-hydroxy-3-hydroxymethylbut-1-yl)-guanine, 9-[4-hydroxy-3-(hydroxymethyl)but-1-yl]guanineCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingTenofovir disoproxil
go.drugbank.com/drugs/DB00300ApprovedInvestigationalTenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name _Viread_, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase … This drug is prescribed in combination with other drugs for the management of HIV infection as well as for Hepatitis B therapy. Tenofovir disoproxil was initially approved in 2001 [FDA label].
Mixtures: TENARTA®L, TOLAK® E 300/200Categories: P-glycoprotein inhibitors, P-glycoprotein substratesErtapenem
go.drugbank.com/drugs/DB00303ApprovedInvestigationalErtapenem is a 1-β methyl-carbapenem that is structurally related to beta-lactam antibiotics.[L14339] It was first authorized for use in the US in November 2001 and in Europe in April 2002. … [A447] Shown to be effective against a wide range of Gram-positive and Gram-negative aerobic and anaerobic bacteria, ertapenem is used to treat various bacterial infections.
Synonyms: (1R,5S,6S,8R,2'S,4'S)-2-(2-(3-carboxyphenylcarbamoyl)pyrrolidin-4-ylthio)-6-(1-hydroxyethyl)-1-methylcarbapenem-3-carboxylic acid, (4R,5S,6S)-3-((3S,5S)-5-((3-carboxyphenyl)carbamoyl)pyrrolidin-3-ylthio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acidCategories: Heterocyclic Compounds, 2-RingPiperacillin
go.drugbank.com/drugs/DB00319ApprovedInvestigationalSemisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections. It is also used in combination with other antibiotics.
Synonyms: (2S,5R,6R)-6-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acidMixtures: AUROTAZ-P 4.5 G, TAZOJECT 2 G/ 0,25G IV ENJEKSIYONLUK LIYOFILIZE TOZ, 1 ADETDihydroergotamine
go.drugbank.com/drugs/DB00320ApprovedInvestigational[A239569] The recently approved Precision Olfactory Delivery technology developed by Impel Neuropharma technology has correlated with an increase of 3-fold in Cmax and 4-fold in AUC despite the solution … A 9,10alpha-dihydro derivative of [ergotamine]. Dihydroergotamine is used as an abortive therapy for migraines.
Synonyms: (2R,4R,7R)-N-[(1S,2S,4R,7S)-7-benzyl-2-hydroxy-4-methyl-5,8-dioxo-3-oxa-6,9-diazatricyclo[7.3.0.02,6]dodecan-4-yl]-6-methyl-6,11-diazatetracyclo[7.6.1.02,7.012,16]hexadeca-1(16),9,12,14-tetraene-4-carboxamide, 5'-benzyl-12'-hydroxy-2'-methyl-3',6',18-trioxo-9,10-dihydroergotamanCategories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, P-glycoprotein inhibitorsHydromorphone
go.drugbank.com/drugs/DB00327ApprovedIllicitInvestigationalStructurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 and 8. … [A176471] Even though hydromorphone does not present a 6-hydroxyl group, it is categorized under the family of phenanthrenes and it is considered a chemical under the schedule II (medical purposes with
Synonyms: 6-Deoxy-7,8-dihydro-6-oxomorphine, 4,5-Epoxy-3-hydroxy-17-methylmorphinan-6-oneCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesOlanzapine
go.drugbank.com/drugs/DB00334ApprovedInvestigational[A176996] Its chemical structure contains a thieno[2,3-b][1,5]benzodiazepine core, and has a methyl group attached to the piperazine ring. … Olanzapine is a thienobenzodiazepine derivative and an atypical or second-generation antipsychotic agent.
Synonyms: 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepineMixtures: TARGET 3 MG /25 MG KAPSUL, 90 ADET, TARGET 6 MG /25 MG KAPSUL, 90 ADET