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Displaying results 61 - 70 of 273 in total
  1. Target

    Hydrolase

    go.drugbank.com/bio_entities/BE0002837
    TargetAlicyclobacillus acidocaldarius

    Polypeptides: Hydrolase
  2. Target

    Serpin H1

    go.drugbank.com/bio_entities/BE0013364
    TargetHumans

    Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen

    Synonyms: Collagen-binding protein, ColliginFunction: collagen binding
  3. Target

    Adiponectin receptor

    go.drugbank.com/bio_entities/BE0010287
    TargetHumans

    Required for normal glucose and fat homeostasis and for maintaining a normal body weight. … Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis.

    Synonyms: Progestin and adipoQ receptor family member 1, Progestin and adipoQ receptor family member I
  4. Target

    Parathion hydrolase

    go.drugbank.com/bio_entities/BE0004036
    TargetEnzymeBrevundimonas diminuta

    It catalyzes the hydrolysis of the insecticide paraoxon at a rate approaching the diffusion limit and thus appears to be optimally evolved for utilizing this synthetic substrate. … The identity of any naturally occurring substrate for the enzyme is unknown. Has no detectable activity with phosphate monoesters or diesters and no activity as an esterase or protease.

    Polypeptides: Parathion hydrolase
  5. Target

    Bleomycin hydrolase

    go.drugbank.com/bio_entities/BE0004697
    EnzymeHumans

    thus protecting normal and malignant cells from BLM toxicity … The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety

    Polypeptides: Bleomycin hydrolaseSynonyms: BLM hydrolase
  6. Target

    Platelet glycoprotein 4

    go.drugbank.com/bio_entities/BE0010538
    TargetTransporterHumans

    Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long … - and very long-chain fatty acids and bacterial diacylated lipopeptides.

    Synonyms: Platelet collagen receptor
  7. Target

    Phosphonoacetaldehyde hydrolase

    go.drugbank.com/bio_entities/BE0003136
    TargetBacillus cereus

    Involved in phosphonate degradation.

    Polypeptides: Phosphonoacetaldehyde hydrolase
  8. Target

    Parathion hydrolase

    go.drugbank.com/bio_entities/BE0001535
    TargetFlavobacterium sp. (strain ATCC 27551)

    It catalyzes the hydrolysis of the insecticide paraoxon at a rate approaching the diffusion limit and thus appears to be optimally evolved for utilizing this synthetic substrate (By similarity). … The identity of any naturally occurring substrate for the enzyme is unknown. Has no detectable activity with phosphate monoesters or diesters and no activity as an esterase or protease.

    Polypeptides: Parathion hydrolase
  9. Target

    Phosphonoacetate hydrolase

    go.drugbank.com/bio_entities/BE0002508
    TargetPseudomonas fluorescens

    Specifically hydrolyzes phosphonoacetate. Does not have activity on other organophosphonates or acetates.

    Polypeptides: Phosphonoacetate hydrolase
  10. Target

    Putative hydrolase DDAH2

    go.drugbank.com/bio_entities/BE0000608
    TargetHumans

    Putative hydrolase with unknown substrate (Probable). Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS (PubMed:21493890, PubMed:37296100). … In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase (

    Polypeptides: Putative hydrolase DDAH2