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Spironolactone Action Pathway
smpdb.ca/view/SMP0000134Drug actionAldosterone increases sodium reabsorption and potassium excretion by up-regulating the expression of basolateral sodium-potassium ATPases as well as luminal (apical) sodium and potassium channels. … Potassium entering the nephron lumen is subsequently excreted in the urine.
Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3Quinethazone Action Pathway (old)
smpdb.ca/view/SMP0000091Drug actionIn the case of quinethazone, it inhibits the sodium-chloride symporter, solute carrier family 12 member 3. Thiazides also inhibit sodium ion transport. … The short term mechanism of action is relatively well-understood: thiazides inhibit sodium-chloride co-transport into the renal distal convoluted tubule of the nephron and therefore increase fluid loss
Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3Amiloride Action Pathway
smpdb.ca/view/SMP0000133Drug actionThe drug is also potassium sparing. Potassium is typically excreted due to the electrochemical gradient produced by sodium reabsorption. … Amiloride causes an increase in sodium excretion and a decrease in potassium secretion. The drug is typically prescribed to patients with depleted potassium.
Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3Cystinuria
smpdb.ca/view/SMP0000723DiseaseCystinuria is a genetic condition caused by mutations in the SLC7A9 or SLC3A1 gene. These two genes are responsible for creating subunits of a protein that reabsorbs cystine into the blood, located in the kidneys. The mutations cause thi...
Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3Torsemide Action Pathway
smpdb.ca/view/SMP0000118Drug actionTorsemide, also known as torasemide is a pharmacologically-active small molecule that belongs to the drug class of loop diuretics. It is commonly used to manage hypertension and edema in cases of congestive heart failure as it acts as a ...
Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3Iminoglycinuria
smpdb.ca/view/SMP0000193DiseaseIminoglycinuria, also called familial iminoglycinuria, is an autosomal recessive disorder of renal reabsorption caused primarily by a defective SLC36A2 gene. SLC36A2 codes for a proton-coupled amino acid transporter which facilitates the...
Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3Blue Diaper Syndrome
smpdb.ca/view/SMP0000583DiseaseBlue diaper syndrome is a recessive metabolic disorder that has not yet been determined to be X-linked or autosomal. This syndrome is caused by a mutation in the large neutral amino acids transporter small subunit 1 protein, which allows...
Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3Lysinuric Protein Intolerance (LPI)
smpdb.ca/view/SMP0000585DiseaseLysinuric protein intolerance (LPI), also called hyperdibasic aminoaciduria, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of the kidney function pathway. It is caused by a mutation in the SLC7A7 gene which ...
Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3Glucose Transporter Defect (SGLT2)
smpdb.ca/view/SMP0000184DiseaseSGLT2 is a sodium/glucose co-transporter that exists almost exclusively in kidney tissue. It is responsible for approximately 90% of the kidney's reabsorption of glucose, and can be found in the S1 segment of the proximal convoluted tubu...
Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3Hartnup Disorder
smpdb.ca/view/SMP0000189DiseaseHartunup Disorder (HND, Hartnup Disease) is an autosomal recessive disease caused by a mutation in the SLC6A19 which codes for sodium-dependent neutral amino acid transporter B(0). A deficiency in this enzyme results in accumulation of L...
Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3