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Pyrimethamine
go.drugbank.com/drugs/DB00205ApprovedInvestigationalVet approvedOne of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.
Mixtures: Rhobazin Plus Solution for Oral UseCategories: Antibiotics for Pneumocystis PneumoniaAdefovir dipivoxil
go.drugbank.com/drugs/DB00718ApprovedAdefovir dipivoxil, previously called bis-POM PMEA, with trade names Preveon and Hepsera, is an orally-administered acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI) used for treatment
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseIbalizumab
go.drugbank.com/drugs/DB12698ApprovedInvestigationalThis drug was approved in March 2018 for the management of treatment-resistant HIV [L1554]. … In October 2022, the FDA approved the administration of Trogarzo (ibalizumab-uiyk) by intravenous push, allowing for a faster drug administration.[L43443,L43448]
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseOdevixibat
go.drugbank.com/drugs/DB16261ApprovedInvestigational[A236808,L34793] Odevixibat is the first approved non-surgical treatment option for PFIC.[L34803] Previous therapies for PFIC included a bile acid sequestrant such as [ursodeoxycholic acid]. … Odevixibat, or A4250, is an ileal sodium/bile acid cotransporter inhibitor indicated for the treatment of pruritus in patients older than 3 months, with progressive familial intrahepatic cholestasis (PFIC
Fostemsavir
go.drugbank.com/drugs/DB11796ApprovedInvestigationalas a potential target of interest in the treatment of HIV-1 infection is relatively recent, and was born out of a desire to find alternative target proteins (i.e. mechanistically orthogonal therapies) for … subunits is a new and novel therapeutic approach to HIV-1 infection, and the addition of attachment inhibitors, like temsavir, to the armament of therapies targeted against HIV-1 fills a necessary niche for
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseGrepafloxacin
go.drugbank.com/drugs/DB00365ApprovedWithdrawnDue to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseProcaine
go.drugbank.com/drugs/DB00721ApprovedInvestigationalVet approvedIt is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
Mixtures: Sterile Concentrate For Cardioplegia InfusionCategories: Agents for Treatment of Hemorrhoids and Anal Fissures for Topical UseGlucarpidase
go.drugbank.com/drugs/DB08898ApprovedInvestigationalfor therapeutic purposes. … [L39855] High-dose [methotrexate], an antifolate agent, has been widely and safely used for many decades in treating various cancers; however, even with aggressive hydration, urine alkalinization, and
Categories: Detoxifying Agents for Antineoplastic TreatmentUndecylenic acid
go.drugbank.com/drugs/DB11117ApprovedIt serves as an acid moiety for anabolic steroid boldenone. … Undecylenic acid also possesses antifungal properties, but is never used on its own for antifungal purposes.
Categories: Antifungals for Topical Use, Antifungals for Dermatological UseCarbinoxamine
go.drugbank.com/drugs/DB00748ApprovedCarbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. … The product label for carbinoxamine as an over the counter cough and cold medicine is being modified to state "do not use" in children under 4 years of age in order to prevent and reduce misuse, as many
Categories: Antihistamines for Systemic Use