Grepafloxacin

DB00365ApprovedWithdrawnSmall molecule

Grepafloxacin is a fluoroquinolone antibiotic used to treat various gram positive and gram negative bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States.

Chemical structure of Grepafloxacin
Mechanism
Curator reviewed
Primary indication
For treatment of adults with mild to moderate infections caused by susceptible strains of Haemophilus influenzae, Streptococcus pneumoniae, or Moraxella catarrhalis.Curator reviewed
Formula / weight
C19H22FN3O3 · 359.3947 g/mol (avg)
First approval
Canada, 1998

Resolves to

Compound
UNIIL1M1U2HC31CAS119914-60-2ChEMBLCHEMBL583ChEBI5543PubChem72474KEGGC11368
Clinical / RWD
RxNorm83719ATCJ01MA11PharmGKBPA449812
Structure
InChIKeyAIJTTZAVMXIJGM-UHFFFAOYSA-NSMILESCC1CN(CCN1)C1=C(F)C(C)=C2C(=O)C(=CN(C3CC3)C2=C1)C(O)=O
Targets
P43700gyrAP43702parCP0A0K8gyrBP20831gyrA
Transporters
P08183ABCB1P33527ABCC1Q4U2R8SLC22A6O15244SLC22A2O76082SLC22A5Q92887ABCC2

What you can answer from here — as of September 23, 2026

4Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
6TransportersSubstrate / inhibitor direction, not just membership
Listed above
1,179Drug interactionsStructured to mechanism, not free text
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1Clinical trialPhase, status and sponsor resolved per trial
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21Marketed productsAcross 2 countries and 1 labeller
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1ATC codeIncluding every combination product, plus 25 drug categories
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23+ReferencesStructured and connected to the statements they support
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