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Nesolicaftor
go.drugbank.com/drugs/DB15239InvestigationalNesolicaftor (PTI-428) is under investigation in clinical trial NCT03258424 (Study Assessing PTI-428 Safety, Tolerability, and Pharmacokinetics in Subjects With Cystic Fibrosis on KALYDECO® as Background
Synonyms: N-(trans-3-(5-((R)-1-hydroxyethyl)-1,3,4-oxadiazol-2-yl)cyclobutyl)-3-phenylisoxazole-5-carboxamideNemiralisib
go.drugbank.com/drugs/DB16253InvestigationalNemiralisib is under investigation in clinical trial NCT03345407 (Dose Finding Study of Nemiralisib (GSK2269557) in Subjects With an Acute Moderate or Severe Exacerbation of Chronic Obstructive Pulmonary
Pemlimogene merolisbac
go.drugbank.com/drugs/DB16286InvestigationalPemlimogene merolisbac is under investigation in clinical trial NCT03371381 (An Efficacy and Safety Study of JNJ-64041757, a Live Attenuated Listeria Monocytogenes Immunotherapy, in Combination With Nivolumab … Versus Nivolumab Monotherapy in Participants With Advanced Adenocarcinoma of the Lung).
Synonyms: Recombinant live-attenuated double-deleted (ladd) strain of listeria monocytogenes (lm .delta.acta/.delta.inlb) expressing a fusion protein comprising the n-terminal 100 amino acids of the lm acta proteinCholesterol
go.drugbank.com/drugs/DB04540ApprovedInvestigationalWithdrawnThe principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
Synonyms: Cholest-5-en-3beta-ol, (3β,14β,17α)-cholest-5-en-3-olOlenasufligene relduparvovec
go.drugbank.com/drugs/DB16264InvestigationalOlenasufligene relduparvovec is under investigation in clinical trial NCT03612869 (Study of aavrh10-h.sgsh Gene Therapy in Patients With Mucopolysaccharidosis Type IIIA (MPS IIIA)). … It is an adeno-associated virus (AAV) vector that delivers a functional copy of the human SGSH gene.[L46671]
Synonyms: Dna (recombinant adeno-associated virus 2 vector lys-saf302 human n-sulfoglucosamine sulfohydrolase cdna-specifying)SOBI-003
go.drugbank.com/drugs/DB15451InvestigationalIt is under investigation in clinical trial NCT03811028 (A Study to Assess the Safety, Tolerability, and Efficacy of Long-term SOBI003 Treatment in Pediatric MPS IIIA Patients). … SOBI-003 is a chemically modified variant of a recombinant human sulfamidase.