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Motixafortide
go.drugbank.com/drugs/DB14939ApprovedInvestigationaltwo apheresis procedures, compared to ~26% of patients receiving only filgrastim. … Motixafortide is a cyclic peptide hematopoietic stem cell mobilizer used to improve stem cell collection prior to autologous transplantation.
Xenon Xe-129
go.drugbank.com/drugs/DB17386ApprovedInvestigational[Helium-3] (He-3) is the one most commonly used due to its strong signal and favorable safety profile, but its use in other applications has affected its availability. … They undergo a process that increases nuclear polarization up to five orders of magnitude, leading to a higher MRI signal.
Rofecoxib
go.drugbank.com/drugs/DB00533ApprovedWithdrawnThe introduction of one or more hydroxyl groups to a phenyl ring lead to stilbenoids. … This compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene moiety.
Ublituximab
go.drugbank.com/drugs/DB11850ApprovedInvestigationalwas approved by the US FDA for the treatment of relapsing forms of multiple sclerosis, becoming the first and only anti-CD20 monoclonal antibody for multiple sclerosis allowing for administration in a one-hour … [A244210] Ublituximab is a chimeric anti-CD20 IgG1κ antibody produced in the rat YB2/0 cell line to target a unique epitope and enhance ADCC compared to other approved anti-CD20 antibodies such as [rituximab
Itraconazole
go.drugbank.com/drugs/DB01167ApprovedInvestigationalFirst synthesized in the early 1980s, itraconazole is a broad-spectrum triazole antifungal agent used to treat a variety of infections. … [A34257] It is a 1:1:1:1 racemic mixture of four diastereomers, made up of two enantiomeric pairs, each possessing three chiral centers.
Synonyms: (SUP 2)-1,2,4-TRIAZOLIN-5-ONE, 3H-1,2,4-TRIAZOL-3-ONE, 4-(4-(4-(4-((2-(2,4-DICHLOROPHENYL)-2-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL)METHOXY)PHENYL)-1-PIPERAZINYL)PHENYL)-2,4-DIHYDRO-2-(1-METHYLPROPYL)-Products: ITRACONAZOLO DOC GENERICI, ITRACONAZOLO MYLAN GENERICSNirmatrelvir
go.drugbank.com/drugs/DB16691ApprovedInvestigationalmild-to-moderate COVID-19. … [L33359] In December 2021, the FDA granted an emergency use authorization to Paxlovid, a co-packaged product containing both nirmatrelvir and [ritonavir], for the treatment of certain patients with
HGTV-43
go.drugbank.com/drugs/DB05807ExperimentalHGTV43 is one of a number of so-called 'gene transfer vectors' developed by the biotechnology company Enzo Biochem, Inc. … HGTV43 is an anti-sense treatment designed to produce T cells that are genetically resistant to HIV infection.
Antihemophilic factor (recombinant), PEGylated
go.drugbank.com/drugs/DB09329ApprovedInvestigationalFactor (Recombinant), PEGylated, is a recombinant full-length human coagulation factor VIII (2,332 amino acids with a molecular weight (MW) of approximately 280 kDa) covalently conjugated with at least one … PEGylation is the covalent attachment of a polyethylene glycol polymer, called PEG, to a drug or protein.
Loteprednol etabonate
go.drugbank.com/drugs/DB14596ApprovedMoreover, LE was purposefully engineered to be a 'soft drug', one that is designed to be active locally at the site of administration and then rapidly metabolized to inactive components after eliciting … enhance patient compliance and simplified dosing compared to all other similar ocular steroids that are dosed four times daily [L4545].
Voretigene neparvovec
go.drugbank.com/drugs/DB13932ApprovedInvestigationalVoretigene Neparvovec-rzyl (VN-rzyl) is an adeno-associated virus vector-based gene therapy. An adeno-associated virus is a small virus that infects humans and other primates. It is not pathogenic and it causes a very mild immune respons...