Xenon Xe-129 is as a hyperpolarized contrast agent, it is indicated for use with magnetic resonance imaging (MRI) for evaluation of lung ventilation. Lung MRIs are challenging due to the low proton density of this tissue, as well as the presence of artifacts due to respiration and cardiovascular pulsation movement and air–tissue interfaces.
- Mechanism
- Curator reviewed · 2 references
The nuclear polarisation of xenon-129 (Xe-129) is increased up to five orders of magnitude in a process called hyperpolarization. This process compensates for the low density of gas compared to that of solid tissue.
After being inhaled, hyperpolarized xenon-129 (Xe-129) is distributed throughout the ventilated lung. Lung ventilation can be visualized using a multi-nuclear capable magnetic resonance imaging (MRI) scanner with a Xe-129 MRI coil.
- Primary indication
- Hyperpolarized Xenon-129 is a contrast agent indicated for use with magnetic resonance imaging (MRI) for the evaluation of lung ventilation in adults and pediatric patients aged 12 years and older.Curator reviewed · 1 structured indication
- Formula / weight
- Xe · 128.9048 g/mol (avg)
- First approval
- United States, 2022
- Also known as
- 129Xe · hyperpolarized 129Xe · Xenon xe-129m · Xenon-129m · Xenon, isotope of mass 129
- Code names
- XE-129M · Xenon-129 · XENON XE-129
Resolves to
FHNFHKCVQCLJFQ-YPZZEJLDSA-NSMILES[129Xe]What you can answer from here — as of July 08, 2026
Which drugs share a target with Xenon Xe-129, and which of those have an active Phase 3 trial?
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