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Albumin human
go.drugbank.com/drugs/DB00062ApprovedInvestigationalThis is a biosimilar drug to existing human serum albumin and was approved for a biological license at both 5% and 25% concentrations by the FDA on June 21, 2018 [L3101]. … Also known as _Albuminex_ 5% or 25%, one brand of human serum albumin is prepared from the pooled plasma of US donors in FDA-licensed facilities in the US [F229].
Mixtures: Sterile Diluent for Allergenic ExtractProducts: Albunorm 5%, 50 g/l, Solution for Infusion, Albunorm 20%, 200 g/l, Solution for InfusionTofacitinib
go.drugbank.com/drugs/DB08895ApprovedInvestigationalTofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. … It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant to methotrexate.
Categories: Biologics for Rheumatoid Arthritis TreatmentNelfinavir
go.drugbank.com/drugs/DB00220ApprovedInvestigationalNelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.[L36485] … Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children.
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseInfliximab
go.drugbank.com/drugs/DB00065ApprovedInvestigationalInfliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions [A31469]. … They are approved for all eligible indications of the reference product. Inflectra, a first biosimilar drug product, was approved in 2016.
Categories: Biologics for Rheumatoid Arthritis TreatmentProducts: POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 100 MG/VIAL, REMICADE POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 100 mg/vialFexofenadine
go.drugbank.com/drugs/DB00950ApprovedInvestigational[L4269] It is selective for the H<sub>1</sub> receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier[L10779] - this is in contrast to previous first-generation … [A1452] Fexofenadine is the major active metabolite of [terfenadine][A1495] and is administered as a racemic mixture in which both enantiomers display approximately equivalent antihistamine activity.
Categories: Antihistamines for Systemic UseSodium acetate
go.drugbank.com/drugs/DB09395ApprovedInvestigationalIt can be used also in metabolic acidosis and for urine alkalinization. … Sodium Acetate is chemically designated CH3COONa, a hygroscopic powder very soluble in water.
Mixtures: D-12043 Sol Conc Electrolyt Pour Dialy, Plasma-Lyte AFenofibric acid
go.drugbank.com/drugs/DB13873ApprovedInvestigational[A32038,L12855] Due to its high hydrophilicity and poor absorption profile,[A32038] prodrug ,[fenofibrate], and other conjugated compounds of fenofibric acid, such as choline fenofibrate, have been developed … Fenofibric acid is a lipid-lowering agent that is used in severe hypertriglyceridemia, primary hyperlipidemia, and mixed dyslipidemia.
Categories: Hypolipidemic Agents Indicated for Hyperlipidemia, Non-statin Hypolipidemic Agents Indicated for HyperlipidemiaTocopherol
go.drugbank.com/drugs/DB11251ApprovedInvestigationalTocopherol, as a group, is composed of soluble phenolic compounds that consist of a chromanol ring and a 16-carbon phytyl chain. … The different types of tocopherol can be presented trimethylated, dimethylated or methylated in the positions 5-, 7- and 8-.
Mixtures: Cernevit, Lyophilisate for ReconstitutionCategories: Compounds used in a research, industrial, or household settingOdevixibat
go.drugbank.com/drugs/DB16261ApprovedInvestigational[A236808,L34793] Odevixibat is the first approved non-surgical treatment option for PFIC.[L34803] Previous therapies for PFIC included a bile acid sequestrant such as [ursodeoxycholic acid]. … Odevixibat, or A4250, is an ileal sodium/bile acid cotransporter inhibitor indicated for the treatment of pruritus in patients older than 3 months, with progressive familial intrahepatic cholestasis (PFIC
Adenosine phosphate
go.drugbank.com/drugs/DB00131ApprovedInvestigationalNutraceuticalWithdrawnAdenosine phosphate was withdrawn by the FDA since it was considered neither safe nor effective for its intended uses as a vasodilator and an anti-inflammatory.[L43937] … Adenosine phosphate, or adenylic acid, is an adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.