Sodium acetate

Identification

Name
Sodium acetate
Accession Number
DB09395
Description

Sodium Acetate is chemically designated CH3COONa, a hygroscopic powder very soluble in water. Sodium acetate could be used as additives in food, industry, concrete manufacture, heating pads and in buffer solutions. Medically, sodium acetate is important component as an electrolyte replenisher when given intravenously. It is mainly indicated to correct sodium levels in hyponatremic patients. It can be used also in metabolic acidosis and for urine alkalinization.

Type
Small Molecule
Groups
Approved, Investigational
Structure
Thumb
Weight
Average: 82.0338
Monoisotopic: 82.003074015
Chemical Formula
C2H3NaO2
Synonyms
  • Acetato de sodio
  • acetic acid, sodium salt
  • Acetic acid, sodium salt (1:1)
  • anhydrous sodium acetate
  • Natriumazetat
  • Sodio acetato
  • Sodium acetate anhydrous
  • Sodium acetate, anhydrous
  • Sodium acetate,anhydrous
External IDs
  • Fema no. 3024

Pharmacology

Indication

Injection, USP 40 mEq is indicated as a source of sodium, for addition to large volume intravenous fluids to prevent or correct hyponatremia in patients with restricted or no oral intake. It is also useful as an additive for preparing specific intravenous fluid formulas when the needs of the patient cannot be met by standard electrolyte or nutrient solutions. Sodium acetate and other bicarbonate precursors are alkalinising agents, and can be used to correct metabolic acidosis, or for alkalinisation of the urine.

Associated Conditions
Associated Therapies
Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
Learn More
Pharmacodynamics

Sodium is the principal cation of extracellular fluid. It comprises more than 90% of total cations at its normal plasma concentration of approximately 140 mEq/liter. The sodium ion exerts a primary role in controlling total body water and its distribution. Acetate ions acts as hydrogen ion acceptor which is alternative to bicarbonate.

Mechanism of action

It works as a source of sodium ions especially in cases of hyponatremic patients. Sodium has a primary role in regulating extracellular fluid volume. It controls water distribution, fluid and electrolyte balance and the osmotic pressure of body fluids. Sodium is also involved in nerve conduction, muscle contraction, acid-base balance and cell nutrient uptake.

Absorption

It is readily available in the circulation after IV administration.

Volume of distribution
Not Available
Protein binding
Not Available
Metabolism

In liver, sodium acetate is being metabolized into bicarbonate. To form bicarbonate, acetate is slowly hydrolyzed to carbon dioxide and water, which are then converted to bicarbonate by the addition of a hydrogen ion.

Route of elimination

Both the sodium and bicarbonate ions are excreted mainly in the urine. Some sodium is excreted in the feces, and small amounts may also be excreted in saliva, sweat, bile and pancreatic secretions.

Half-life
Not Available
Clearance
Not Available
Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More
Toxicity

LD50: 25956 mg/kg (Rat.)

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbacavirAbacavir may decrease the excretion rate of Sodium acetate which could result in a higher serum level.
AcarboseAcarbose may decrease the excretion rate of Sodium acetate which could result in a higher serum level.
AceclofenacAceclofenac may decrease the excretion rate of Sodium acetate which could result in a higher serum level.
AcemetacinAcemetacin may decrease the excretion rate of Sodium acetate which could result in a higher serum level.
AcetaminophenAcetaminophen may decrease the excretion rate of Sodium acetate which could result in a higher serum level.
AcetazolamideAcetazolamide may increase the excretion rate of Sodium acetate which could result in a lower serum level and potentially a reduction in efficacy.
Acetylsalicylic acidAcetylsalicylic acid may decrease the excretion rate of Sodium acetate which could result in a higher serum level.
AclidiniumAclidinium may decrease the excretion rate of Sodium acetate which could result in a higher serum level.
AcrivastineSodium acetate may decrease the excretion rate of Acrivastine which could result in a higher serum level.
AcyclovirAcyclovir may decrease the excretion rate of Sodium acetate which could result in a higher serum level.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

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Food Interactions
No interactions found.

Products

Product Ingredients
IngredientUNIICASInChI Key
Sodium acetate trihydrate4550K0SC9B6131-90-4AYRVGWHSXIMRAB-UHFFFAOYSA-M
Active Moieties
NameKindUNIICASInChI Key
Acetic acidprodrugQ40Q9N063P64-19-7QTBSBXVTEAMEQO-UHFFFAOYSA-N
Acetateionic569DQM74SC71-50-1QTBSBXVTEAMEQO-UHFFFAOYSA-M
Sodium cationionicLYR4M0NH3717341-25-2FKNQFGJONOIPTF-UHFFFAOYSA-N
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
16.4% Sodium Acetate Injection, USPSolutionIntravenousBaxter Laboratories2003-02-132011-05-10Canada flag
Sodium AcetateInjection, solution, concentrate164 mg/1mLIntravenousAmerican Regent1990-09-302013-03-01US flag
Sodium AcetateInjection, solution, concentrate3.28 g/20mLIntravenousHospira, Inc.2005-03-31Not applicableUS flag
Sodium AcetateInjection, solution, concentrate164 mg/1mLIntravenousHospira, Inc.2013-11-19Not applicableUS flag
Sodium Acetate Inj 328mg/ml USPLiquidIntravenousLyphomed, Division Of Fujisawa Canada Inc.1984-12-311996-09-10Canada flag
Sodium Acetate Inj 328mg/ml USPLiquidIntravenousSabex Inc1988-12-312008-08-07Canada flag
Sodium Acetate Injection, USPSolutionIntravenousFresenius Kabi1996-08-14Not applicableCanada flag
Sodium Acetate-omegaLiquidIntravenousOmega Laboratories Ltd1999-05-28Not applicableCanada flag
Sodum AcetateInjection, solution, concentrate328 mg/1mLIntravenousAMERICAN REGENT, INC.1990-09-30Not applicableUS flag
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Sodium AcetateInjection, solution, concentrate4 meq/100mLIntravenousFresenius Kabi USA, LLC2017-10-30Not applicableUS flag
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

    Learn more
  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
2.5% Travasol Amino Acid Injection With Electrolytes In 10% DextroseSodium acetate (170 mg) + Alanine (520 mg) + Arginine (290 mg) + Dextrose, unspecified form (10 g) + Dipotassium phosphate (130.5 mg) + Glycine (260 mg) + Histidine (120 mg) + Isoleucine (150 mg) + L-Lysine (145 mg) + Leucine (182.5 mg) + Magnesium chloride (25.5 mg) + Methionine (100 mg) + Phenylalanine (140 mg) + Proline (170 mg) + Serine (125 mg) + Sodium chloride (29.3 mg) + Threonine (105 mg) + Tryptophan (45 mg) + Tyrosine (10 mg) + Valine (145 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1996-12-312015-08-05Canada flag
2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose ClinimixSodium acetate (170 mg) + Alanine (520 mg) + Arginine (260 mg) + Dextrose, unspecified form (10 g) + Dipotassium phosphate (130.5 mg) + Glycine (520 mg) + Histidine (110 mg) + Isoleucine (120 mg) + L-Lysine hydrochloride (145 mg) + L-Leucine hydrochloride (155 mg) + Magnesium chloride (25.5 mg) + Methionine (145 mg) + Phenylalanine hydrochloride (155 mg) + Proline (105 mg) + Sodium chloride (29.3 mg) + Threonine (105 mg) + Tryptophan (45 mg) + Tyrosine (10 mg) + Valine (115 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1993-12-312015-08-05Canada flag
2.5%travasol Amino Acid InJ.W.eleC.W.25%dexSodium acetate (170 mg) + Alanine (520 mg) + Arginine (290 mg) + Dextrose, unspecified form (25 g) + Dipotassium phosphate (130.5 mg) + Glycine (260 mg) + Histidine (120 mg) + Isoleucine (150 mg) + L-Lysine (145 mg) + Leucine (182.5 mg) + Magnesium chloride (25.5 mg) + Methionine (100 mg) + Phenylalanine (140 mg) + Proline (170 mg) + Serine (125 mg) + Sodium chloride (29.3 mg) + Threonine (105 mg) + Tryptophan (45 mg) + Tyrosine (10 mg) + Valine (145 mg)LiquidIntravenousClintec Nutrition Company1996-07-301998-08-13Canada flag
2.75% Travas. Amino Acid InJ.W.elecw.25%dexSodium acetate (215.5 mg) + Alanine (570 mg) + Arginine (316 mg) + Dextrose, unspecified form (25 g) + Dipotassium phosphate (261 mg) + Glycine (283 mg) + Histidine (132 mg) + Isoleucine (165 mg) + L-Lysine (159.5 mg) + Leucine (201 mg) + Magnesium chloride (51 mg) + Methionine (110 mg) + Phenylalanine (154 mg) + Proline (187 mg) + Serine (137.5 mg) + Sodium chloride (112 mg) + Threonine (115.5 mg) + Tryptophan (49.5 mg) + Tyrosine (11 mg) + Valine (159.5 mg)LiquidIntravenousClintec Nutrition Company1996-07-301998-08-13Canada flag
2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose QuickmixSodium acetate (215.5 mg) + Alanine (570 mg) + Arginine (285 mg) + Dextrose, unspecified form (25 g) + Dipotassium phosphate (261 mg) + Glycine (570 mg) + Histidine (120.5 mg) + Isoleucine (131.5 mg) + L-Lysine hydrochloride (159 mg) + L-Leucine hydrochloride (170 mg) + Magnesium chloride (51 mg) + Methionine (159 mg) + Phenylalanine hydrochloride (170 mg) + Proline (115 mg) + Sodium chloride (112 mg) + Threonine (115 mg) + Tryptophan (49.5 mg) + Tyrosine (11 mg) + Valine (126 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1996-02-022007-08-02Canada flag
2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose QuickmixSodium acetate (256 mg) + Alanine (570 mg) + Arginine (285 mg) + Dextrose, unspecified form (5 g) + Dipotassium phosphate (215.5 mg) + Glycine (570 mg) + Histidine (120.5 mg) + Isoleucine (131.5 mg) + L-Lysine hydrochloride (159 mg) + L-Leucine hydrochloride (170 mg) + Magnesium chloride (51 mg) + Methionine (159 mg) + Phenylalanine hydrochloride (170 mg) + Proline (115 mg) + Sodium chloride (112 mg) + Threonine (115 mg) + Tryptophan (49.5 mg) + Tyrosine (11 mg) + Valine (126 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1993-12-312007-08-02Canada flag
2.75%travasol Amino Acid InJ.W.eleC.W.5%dex.Sodium acetate (215 mg) + Alanine (570 mg) + Arginine (316 mg) + Dextrose, unspecified form (5 g) + Dipotassium phosphate (261 mg) + Glycine (283 mg) + Histidine (132 mg) + Isoleucine (165 mg) + L-Lysine (159.5 mg) + Leucine (201 mg) + Magnesium chloride (51 mg) + Methionine (110 mg) + Phenylalanine (154 mg) + Proline (187 mg) + Serine (137.5 mg) + Sodium chloride (112 mg) + Threonine (115.5 mg) + Tryptophan (49.5 mg) + Tyrosine (11 mg) + Valine (159.5 mg)LiquidIntravenousClintec Nutrition Company1996-12-311999-08-10Canada flag
4.25% Travasol Amino Acid Injection With Electrolytes In 10% DextroseSodium acetate (297 mg) + Alanine (880 mg) + Arginine (489 mg) + Dextrose, unspecified form (10 g) + Dipotassium phosphate (261 mg) + Glycine (438 mg) + Histidine (204 mg) + Isoleucine (255 mg) + L-Lysine hydrochloride (246.5 mg) + Leucine (310 mg) + Magnesium chloride (51 mg) + Methionine (170 mg) + Phenylalanine (238 mg) + Proline (289 mg) + Serine (212.5 mg) + Sodium chloride (77 mg) + Threonine (178.5 mg) + Tryptophan (76.5 mg) + Tyrosine (17 mg) + Valine (246.5 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1996-12-312015-08-05Canada flag
4.25% Travasol Amino Acid Injection With Electrolytes In 20% DextroseSodium acetate (297 mg) + Alanine (880 mg) + Arginine (489 mg) + Dextrose, unspecified form (20 g) + Dipotassium phosphate (261 mg) + Glycine (438 mg) + Histidine (204 mg) + Isoleucine (255 mg) + L-Lysine hydrochloride (246.5 mg) + Leucine (310 mg) + Magnesium chloride (51 mg) + Methionine (170 mg) + Phenylalanine (238 mg) + Proline (289 mg) + Serine (212.5 mg) + Sodium chloride (77 mg) + Threonine (178.5 mg) + Tryptophan (76.5 mg) + Tyrosine (17 mg) + Valine (246.5 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1996-12-312007-08-02Canada flag
4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose QuickmixSodium acetate (297 mg) + Alanine (880 mg) + Arginine (440 mg) + Dextrose, unspecified form (20 g) + Dipotassium phosphate (261 mg) + Glycine (880 mg) + Histidine (186 mg) + Isoleucine (203 mg) + L-Lysine hydrochloride (246 mg) + L-Leucine hydrochloride (263 mg) + Magnesium chloride (51 mg) + Methionine (246 mg) + Phenylalanine hydrochloride (263 mg) + Proline (178 mg) + Sodium chloride (77 mg) + Threonine (178 mg) + Tryptophan (76 mg) + Tyrosine (17 mg) + Valine (195 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1995-12-312007-08-02Canada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
ClinimixSodium acetate trihydrate (2.16 g/1L) + Alanine (5.70 g/1L) + Arginine (3.17 g/1L) + Calcium chloride dihydrate (0.33 g/1L) + D-glucose monohydrate (75.00 g/1L) + Dipotassium phosphate (2.61 g/1L) + Glycine (2.84 g/1L) + Histidine (1.32 g/1L) + Isoleucine (1.65 g/1L) + L-Lysine (2.00 g/1L) + Leucine (2.01 g/1L) + Magnesium chloride hexahydrate (0.51 g/1L) + Methionine (1.10 g/1L) + Phenylalanine (1.54 g/1L) + Proline (1.87 g/1L) + Serine (1.38 g/1L) + Sodium chloride (1.12 g/1L) + Threonine (1.16 g/1L) + Tryptophan (0.50 g/1L) + Tyrosine (0.11 g/1L) + Valine (1.60 g/1L)SolutionIntravenousBaxter Healthcare Corporation2017-10-252019-11-30US flag
ClinimixSodium acetate trihydrate (2.16 g/1L) + Alanine (5.70 g/1L) + Arginine (3.17 g/1L) + Calcium chloride dihydrate (0.33 g/1L) + D-glucose monohydrate (100.00 g/1L) + Dipotassium phosphate (2.61 g/1L) + Glycine (2.84 g/1L) + Histidine (1.32 g/1L) + Isoleucine (1.65 g/1L) + L-Lysine (2.00 g/1L) + Leucine (2.01 g/1L) + Magnesium chloride hexahydrate (0.51 g/1L) + Methionine (1.10 g/1L) + Phenylalanine (1.54 g/1L) + Proline (1.87 g/1L) + Serine (1.38 g/1L) + Sodium chloride (1.12 g/1L) + Threonine (1.16 g/1L) + Tryptophan (0.50 g/1L) + Tyrosine (0.11 g/1L) + Valine (1.60 g/1L)SolutionIntravenousBaxter Healthcare Corporation2017-10-252019-11-30US flag
ClinimixSodium acetate trihydrate (5.94 g/2L) + Alanine (17.60 g/2L) + Arginine (9.78 g/2L) + Calcium chloride dihydrate (0.66 g/2L) + D-glucose monohydrate (300.00 g/2L) + Dipotassium phosphate (5.22 g/2L) + Glycine (8.76 g/2L) + Histidine (4.08 g/2L) + Isoleucine (5.10 g/2L) + L-Lysine (4.93 g/2L) + Leucine (6.20 g/2L) + Magnesium chloride hexahydrate (1.02 g/2L) + Methionine (3.40 g/2L) + Phenylalanine (4.76 g/2L) + Proline (5.78 g/2L) + Serine (4.25 g/2L) + Sodium chloride (1.54 g/2L) + Threonine (3.57 g/2L) + Tryptophan (1.53 g/2L) + Tyrosine (0.34 g/2L) + Valine (4.93 g/2L)SolutionIntravenousBaxter Healthcare Corporation2017-10-252019-11-30US flag
Cytosol Ophthalmics - Balanced Salt SolutionSodium acetate trihydrate (3.90 mg/1mL) + Calcium chloride dihydrate (48 mg/1mL) + Magnesium chloride hexahydrate (30 mg/1mL) + Potassium chloride (75 mg/1mL) + Sodium chloride (6.40 mg/1mL) + Sodium citrate dihydrate (1.70 mg/1mL)SolutionIrrigationBiomet Biologics2010-01-012010-09-04US flag
Hyperlyte CRSodium acetate trihydrate (0.68 g/20mL) + Calcium chloride dihydrate (0.37 g/20mL) + Magnesium chloride hexahydrate (0.51 g/20mL) + Potassium acetate (1.96 g/20mL) + Sodium chloride (1.17 g/20mL)Injection, solution, concentrateIntravenousB. Braun Medical Inc.2012-04-12Not applicableUS flag
NutrilyteSodium acetate trihydrate (135 mg/1mL) + Calcium acetate (22 mg/1mL) + Sodium gluconate (55 mg/1mL) + Magnesium acetate (43 mg/1mL) + Potassium acetate (34.5 mg/1mL) + Potassium chloride (125 mg/1mL)Injection, solution, concentrateIntravenousAmerican Regent1990-09-302013-05-08US flag
Nutrilyte IISodium acetate trihydrate (64.6 mg/1mL) + Calcium chloride dihydrate (16.55 mg/1mL) + Magnesium chloride hexahydrate (25.5 mg/1mL) + Potassium acetate (98 mg/1mL) + Sodium chloride (74.5 mg/1mL)Injection, solution, concentrateIntravenousAmerican Regent1990-10-012014-01-01US flag
Nutrilyte IISodium acetate trihydrate (64.6 mg/1mL) + Calcium chloride dihydrate (16.55 mg/1mL) + Magnesium chloride hexahydrate (25.5 mg/1mL) + Potassium acetate (98 mg/1mL) + Sodium chloride (74.5 mg/1mL)Injection, solution, concentrateIntravenousAmerican Regent1990-10-012014-01-01US flag
Prenatal PlusSodium acetate trihydrate (2000 [iU]/1) + Ascorbic acid (120 mg/1) + Beta carotene (2000 [iU]/1) + Calcium carbonate (200 mg/1) + Cholecalciferol (400 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + DL-alpha tocopheryl acetate (22 mg/1) + Ferrous fumarate (27 mg/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (3 mg/1) + Thiamine mononitrate (1.84 mg/1) + Zinc oxide (25 mg/1)TabletOralSeton Pharmaceuticals2014-03-072017-01-26US flag
Sodium AcetateSodium acetate (164 mg/1mL)Injection, solution, concentrateIntravenousAmerican Regent1990-09-302013-03-01US flag

Categories

ATC Codes
B05XA08 — Sodium acetate
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as acetate salts. These are organic compounds containing acetic acid as its acid component.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Carboxylic acid derivatives
Direct Parent
Acetate salts
Alternative Parents
Monocarboxylic acids and derivatives / Carboxylic acids / Organic sodium salts / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Acetate salt / Aliphatic acyclic compound / Carbonyl group / Carboxylic acid / Hydrocarbon derivative / Monocarboxylic acid or derivatives / Organic alkali metal salt / Organic oxide / Organic oxygen compound / Organic salt
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
organic sodium salt (CHEBI:32954)

Chemical Identifiers

UNII
NVG71ZZ7P0
CAS number
127-09-3
InChI Key
VMHLLURERBWHNL-UHFFFAOYSA-M
InChI
InChI=1S/C2H4O2.Na/c1-2(3)4;/h1H3,(H,3,4);/q;+1/p-1
IUPAC Name
sodium acetate
SMILES
[Na+].CC([O-])=O

References

General References
  1. rxlist [Link]
  2. monograph [Link]
PubChem Compound
517045
PubChem Substance
347827840
ChemSpider
29105
RxNav
267453
ChEBI
32954
ChEMBL
CHEMBL1354
PharmGKB
PA451369
Wikipedia
Sodium_acetate
AHFS Codes
  • 40:12.00 — Replacement Preparations

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4RecruitingBasic ScienceNephrotoxicity1
4RecruitingSupportive CareIllness, Critical1
4RecruitingTreatmentHypovolaemia1
4TerminatedSupportive CareCancer-related Malnutrition1
4TerminatedTreatmentDehydration / Gastroenteritis1
4WithdrawnSupportive CareMalnutrition1
3Active Not RecruitingPreventionAcute Kidney Injury (AKI) / Illness, Critical1
3Active Not RecruitingTreatmentDelayed Graft Function / End Stage Kidney Disease / Kidney Transplant; Complications1
3CompletedTreatmentAnaesthesia therapy1
3CompletedTreatmentGeneral Surgery / Parenteral Nutrition1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SolutionIntravenous
LiquidHemodialysis
SolutionIntravenous2.453 g
SolutionIntraocular
SolutionOphthalmic
SolutionIntraocular; Irrigation1950 mg
SolutionIntravenous0.64 g/100ml
SolutionIntravenous5 g/100ml
SolutionHemodialysis
SolutionIrrigation
SolutionIntravenous6.4 g/L
SolutionIntravenous1.63 g
LiquidIntraocular
Solution0.64 g/100ml
SolutionIntravenous0.64 %
SolutionIntravenous5 %
SolutionIntravenous0.03 %
SolutionIntravenous0.37 %
SolutionIntravenous
Injection, emulsionIntravenous
InjectionIntravenous110 g
InjectionIntravenous165 g
InjectionIntravenous220 g
InjectionIntravenous275 g
InjectionIntravenous107 g
InjectionIntravenous143 g
InjectionIntravenous178 g
SolutionIntravenous20.475 %
LiquidIntravenous
SolutionIntravenous0.368 g
SolutionIntravenous55 g/L
Solution0.53 g/100ml
Solution16 g/L
Injection, emulsionIntravenous1.6 g/100mL
Injection, emulsion; injection, solutionIntravenous3.2 g/100mL
EmulsionIntravenous20 mg
EmulsionIntravenous16 g
Injection, solution, concentrateIntravenous
Injection, emulsionIntravenous1.6 g
InjectionIntravenous2.27 g/l
InjectionIntravenous4.12 g/l
SolutionIntravenous7.14 g
SolutionIntravenous9.52 g
SolutionIntravenous11.9 g
EmulsionIntravenous6.41 g
EmulsionIntravenous9.61 g
EmulsionIntravenous12.82 g
EmulsionIntravenous4 g
SolutionIntraocular; Ophthalmic7.8 mg
EmulsionIntravenous
EmulsionIntravenous3 g
IrrigantIrrigation
SolutionIntravenous368 mg
Injection, solutionIntravenous
SolutionIntravenous0.035 %
Injection, solutionIntravenous0.03 %
Solution3.2 g/100mL
Solution1.6 g/100mL
TabletOral
SolutionParenteral3 g/100ml
EmulsionParenteral50 g
Injection, solution, concentrateIntravenous164 mg/1mL
Injection, solution, concentrateIntravenous3.28 g/20mL
Injection, solution, concentrateIntravenous4 meq/100mL
LiquidIntravenous
Injection, solution, concentrateIntravenous328 mg/1mL
SolutionIntraocular; Irrigation0.39 g
InjectionIntravenous
SolutionIntravenous594 mg
SolutionIntravenous6 g/100mL
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility429.0 mg/mLALOGPS
logP-0.2ALOGPS
logP-0.22ChemAxon
logS0.72ALOGPS
pKa (Strongest Acidic)4.54ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area40.13 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity23.48 m3·mol-1ChemAxon
Polarizability4.96 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available

Enzymes

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
General Function
Atp binding
Specific Function
Activates acetate so that it can be used for lipid synthesis or for energy generation.
Gene Name
ACSS2
Uniprot ID
Q9NR19
Uniprot Name
Acetyl-coenzyme A synthetase, cytoplasmic
Molecular Weight
78579.11 Da
References
  1. article [Link]

Drug created on November 30, 2015 12:10 / Updated on September 27, 2020 08:17

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