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Gilteritinib
go.drugbank.com/drugs/DB12141ApprovedInvestigationalThis drug was approved after being designed as an orphan drug with a fast track and priority review status.[L4830] … [A40036] It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression observed in other therapies.
Categories: MATE 1 Inhibitors, Cytochrome P-450 SubstratesProducts: XOSPATA 40 MG FİLM KAPLI TABLET, 84 ADET, XOSPATA® FILM-COATED TABLETS 40MGPipemidic acid
go.drugbank.com/drugs/DB13823InvestigationalPipemidic acid is a quinolone antibacterial agent with activity against various gram-positive and gram-negative bacteria.[A275138, A275143]
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP1A2 InhibitorsProducts: MIXATO® 400 MG TABLETAS, ACIDO PIPEMIDICO EGChlorprothixene
go.drugbank.com/drugs/DB01239ApprovedInvestigationalWithdrawnChlorprothixene is a typical antipsychotic drug of the thioxanthene (tricyclic) class. … Chlorprothixene exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors.
Categories: P-glycoprotein inhibitors, Heterocyclic Compounds, 3-RingProducts: Truxal 15 mg - Filmtabletten, Truxal 50 mg - FilmtablettenDegarelix
go.drugbank.com/drugs/DB06699ApprovedInvestigationalChemically, it is a synthetic linear decapeptide amide with seven unnatural amino acids, five of which are D-amino acids. FDA approved on December 24, 2008. … Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH.
Products: FIRMAGON ®80MG, FIRMAGON ® 120MGCholic Acid
go.drugbank.com/drugs/DB02659ApprovedInvestigationalA major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. … [PubChem] Cholic acid, formulated as Cholbam capsules, is approved by the United States Food and Drug Administration as a treatment for children and adults with bile acid synthesis disorders due to single
Categories: P-glycoprotein inducersProducts: ORPHACOL®50 MG, ORPHACOL ® 250 MGAlpelisib
go.drugbank.com/drugs/DB12015ApprovedInvestigationalIt works by selectively inhibiting class I PI3K p110α [A179203], which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival … Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Class I Phosphatidylinositol 3-Kinases, antagonists & inhibitorsProducts: PİMREVA 200 MG FİLM KAPLI TABLET, 14 ADET, PİMREVA 200 MG FİLM KAPLI TABLET, 28 ADETPivmecillinam
go.drugbank.com/drugs/DB01605ApprovedInvestigationalPivmecillinam is a mecillinam prodrug, a pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. … It is active against gram-negative organisms and used as for amdinocillin. [PubChem]
Categories: Heterocyclic Compounds, 2-RingProducts: Selexid 200 mg Filmtabletten, Selexid 400 mg film-coated tabletsNaftidrofuryl
go.drugbank.com/drugs/DB13588ApprovedCategories: Heterocyclic Compounds, 1-Ring, Serotonin 5-HT2 Receptor AntagonistsProducts: PRAXILENE TABLET 200 mg, Dusodril retard 100 mg - FilmtablettenDe Novo Triacylglycerol Biosynthesis TG(20:3(5Z,8Z,11Z)/20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))
smpdb.ca/view/SMP0023254MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. … Last, the enzyme diacylglycerol O-acyltransferase synthesizes triacylglycerol from diacylglycerol and a fatty acyl-CoA.
De Novo Triacylglycerol Biosynthesis TG(20:3(5Z,8Z,11Z)/22:4(7Z,10Z,13Z,16Z)/20:4(5Z,8Z,11Z,14Z))
smpdb.ca/view/SMP0023284MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. … Last, the enzyme diacylglycerol O-acyltransferase synthesizes triacylglycerol from diacylglycerol and a fatty acyl-CoA.