DB01239ApprovedInvestigationalWithdrawnSmall molecule
Chlorprothixene is a thioxanthene antipsychotic. Chlorprothixene exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors.
- Mechanism
- Curator reviewed
Chlorprothixene blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
- Primary indication
- For treatment of psychotic disorders (e.g. schizophrenia) and of acute mania occuring as part of bipolar disorders.Curator reviewed · 2 structured indications
- Formula / weight
- C18H18ClNS · 315.86 g/mol (avg)
- Also known as
- Chlorprothixen · Chlorprothixine · Chlorprotixen · Chlorprotixene · Chlorprotixine
Resolves to
Clinical / RWD
Structure
InChIKey
WSPOMRSOLSGNFJ-AUWJEWJLSA-NSMILESCN(C)CC\C=C1\C2=CC=CC=C2SC2=CC=C(Cl)C=C12Transporters
What you can answer from here — as of September 23, 2026
12Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
1TransporterSubstrate / inhibitor direction, not just membershipListed above
Which drugs share a target with Chlorprothixene, and which of those have an active Phase 3 trial?
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