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V-ATPase Subunits
go.drugbank.com/bio_entities/BE0009961TargetHumansSubunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that transports protons across cellular membranes. V-ATPase...
Polypeptides: V-type proton ATPase subunit e 1, V-type proton ATPase subunit E 1Synonyms: V-ATPase subunit e 1, V-ATPase subunit E 1Zidovudine
go.drugbank.com/drugs/DB00495ApprovedInvestigationalThe compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. … A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group.
Mixtures: TREZAV® PED, ZOVILAM PED DT®Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesNuclear receptor coactivator 1
go.drugbank.com/bio_entities/BE0003728TargetHumansNuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR a...
Synonyms: Class E basic helix-loop-helix protein 74Budesonide
go.drugbank.com/drugs/DB01222ApprovedInvestigationalBudesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis. … [L10598] It is also available in a combination product with [formoterol].[L10619]
Mixtures: BUDESONIDE E FORMOTEROLO SANDOZ, BUDESONIDE E FORMOTEROLO SANDOZCategories: P-glycoprotein substrates, Cytochrome P-450 SubstratesRetinol dehydrogenase 16
go.drugbank.com/bio_entities/BE0011917EnzymeHumansOxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes (PubMed:10329026, PubMed:12534290, PubMed:9677409). Has higher activity towards CRBP-bo...
Synonyms: hRDH-EFibronectin receptor
go.drugbank.com/bio_entities/BE0010279TargetHumansIt recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. … Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen.
Synonyms: CD49 antigen-like family member ECarbidopa
go.drugbank.com/drugs/DB00190ApprovedInvestigationalCarbidopa presents a chemical denomination of N-amino-alpha-methyl-3-hydroxy-L-tyrosine monohydrate.
Mixtures: LEVODO CA E P100/25/200, LEVODO CA E P100/25/200Categories: Aromatic L-amino Acid Decarboxylase InhibitorsCetirizine
go.drugbank.com/drugs/DB00341ApprovedInvestigationalOne of the most common uses for this drug is for a condition called _allergic rhinitis_.
Mixtures: NEXT GL GENOMMA LAB®, NEXT GL GENOMMA LAB®Categories: P-glycoprotein inhibitors, P-glycoprotein substratesRamipril
go.drugbank.com/drugs/DB00178ApprovedInvestigationalRamipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. … Ramiprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII).
Mixtures: RAMIPRIL COMP PUR 5/25MG, RAMIPRIL COMP PUR 5/25MGCategories: Heterocyclic Compounds, 2-RingAtorvastatin
go.drugbank.com/drugs/DB01076ApprovedInvestigationalAtorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. … [T568] It is a pentasubstituted pyrrole [A177415] formed by two contrasting moieties with an achiral heterocyclic core unit and a 3,5-dihydroxypentanoyl side chain identical to its parent compound.
Mixtures: TIAZOMET ® A 40/10 TABLETAS, EZETIMIBE E ATORVASTATINA DOCCategories: P-glycoprotein inhibitors, P-glycoprotein substrates