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Displaying results 741 - 750 of 4588 in total
  1. Drug

    Anakinra

    go.drugbank.com/drugs/DB00026
    ApprovedInvestigational

    On November 14, 2001, it was approved by the FDA for the treatment of rheumatoid arthritis.

  2. Drug

    Tiratricol

    go.drugbank.com/drugs/DB03604
    ApprovedInvestigational

    by chronic tissue thyrotoxicosis and abnormal neuronal development due to the impaired thyroid hormone uptake in the brain. … [L53383] It was first approved by the EMA on February 12, 2025 for the treatment of peripheral thyrotoxicosis in patients with monocarboxylate transporter 8 (MCT8) deficiency,[A274038] a disorder characterized

  3. Drug

    Clindamycin

    go.drugbank.com/drugs/DB01190
    ApprovedInvestigationalVet approved

    Clindamycin is a semi-synthetic lincosamide antibiotic used in the treatment of a variety of serious infections due to susceptible microorganisms as well as topically for acne vulgaris. It has a relatively narrow spectrum of activity tha...

  4. Drug

    Isavuconazonium

    go.drugbank.com/drugs/DB06636
    ApprovedInvestigational

    Due to low solubility in water of isavuconazole on its own, the isovuconazonium formulation is favorable as it has high solubility in water and allows for intravenous administration. … , marketed by Astellas under the brand Cresemba.

  5. Drug

    Tedizolid

    go.drugbank.com/drugs/DB14569
    ApprovedInvestigational

    [L11232, A199086, A199050] Tedizolid was approved by the FDA on June 20, 2014, for sale by Cubist Pharmaceuticals as tedizolid phosphate (SIVEXTRO®).

  6. Drug

    Cefonicid

    go.drugbank.com/drugs/DB01328
    Approved

    A second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and sof...

  7. Pathway

    Physostigmine Action Pathway (new)

    smpdb.ca/view/SMP0126616
    Drug action

    Physostigmine is a cholinesterase inhibitor used to treat glaucoma, once administered it is rapidly absorbed and can travel across membranes even the blood-brain barrier. Physostigmine acts on the acetylcholinesterase enzyme and inhibits...

    Drugs: Choline · Physostigmine · Calcium · Magnesium cation · Acetylcholine · Acetic acid
    Enzymes: High affinity choline transporter 1
  8. Pathway

    Tacrine Action Pathway (new)

    smpdb.ca/view/SMP0126621
    Drug action

    Its mechanism of action is not fully known but is thought that the drug reversibly binds and inhibits cholinesterase and acetylcholinesterase.

    Drugs: Choline · Tacrine · Calcium · Magnesium cation · Acetylcholine · Acetic acid
    Enzymes: High affinity choline transporter 1
  9. Drug

    Alprazolam

    go.drugbank.com/drugs/DB00404
    ApprovedIllicitInvestigational

    [L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole. … [L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down a patient's dose to avoid withdrawal symptoms.

  10. Drug

    Influenza A virus A/Croatia/10136RV/2023 X-425A (H3N2) antigen (formaldehyde inactivated)

    go.drugbank.com/drugs/DB21765
    Approved

    These vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which results in an immunological defense against future exposure to the virus, or "antigen … Recombinant influenza vaccines are produced by synthesizing recombinant influenza hemagglutinin antigen in a laboratory and do not require the use of candidate viruses or egg-based manufacturing processes

    Mixtures: Fluzone High Dose Northern Hemisphere, Fluzone High Dose Northern Hemisphere