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Zuclopenthixol
go.drugbank.com/drugs/DB01624ApprovedInvestigationalIt is known that zuclopenthixol is metabolized by Cytochrome P450 2D6. Zuclopenthixol was approved for use in Canada in 2011, but is not approved for use in the United States. … These are organic polycyclic compounds containing a thioxanthene moiety, which is an aromatic tricycle derived from xanthene by replacing the oxygen atom with a sulfur atom.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeTriamterene
go.drugbank.com/drugs/DB00384ApprovedIt works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. … [L6163] Triamterene was approved by the Food and Drug Administration in the U.S. in 1964.
Mixtures: Nu-triazide Tab 50 Mg/25 mgEtafedrine
go.drugbank.com/drugs/DB11587ApprovedThis belongs to the family of medications called _decongestants_. It acts by narrowing blood vessels in the nasal passages, helping to relieve nasal congestion [F6]. … It was previously available as both the free base and as the hydrochloride salt manufactured by Sanofi-Aventis (now Sanofi) has been discontinued [L2563].
Bexagliflozin
go.drugbank.com/drugs/DB12236ApprovedInvestigational[A256423,L44758] In January 2023, bexagliflozin was approved by the FDA for the treatment of adults with type 2 diabetes. … [A256408] By inhibiting SGLT2, bexagliflozin reduces renal reabsorption of filtered glucose and increases urinary glucose excretion, which reduces blood glucose levels independently of insulin sensitivity
Sarecycline
go.drugbank.com/drugs/DB12035ApprovedInvestigationalSarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007 … The acne often presents physically as a mixture of non-inflammatory and inflammatory lesions mainly on the face but on the back and chest as well [L4814].
Aluminum zirconium octachlorohydrex gly
go.drugbank.com/drugs/DB11200ApprovedInterestingly, this chemical has been studied in relation to its possible impact on the microbiome of the human underarms [A32967]. … Currently, the FDA allows the inclusion of this substance in concentrations of up to 20% in antiperspirants [L2012].
Mixtures: Lactovit DEODORANT ROLL-ON MEN INVISIBLEProducts: Duke Cannon Bay Rum, Guy Laroche Paris Drakkar Essence Antiperspirant DeodorantEphedra sinica root
go.drugbank.com/drugs/DB01363ApprovedNutraceuticalThe sale of ephedra-containing supplements intended to increase muscle weight or promote weight loss was banned in the United States in 2004 due to the risk for adverse effects and a lack of evidence for
Mixtures: Miller's Formula No. 1Tedizolid phosphate
go.drugbank.com/drugs/DB09042Approved[L11232, A199086, A199050] Tedizolid was approved by the FDA on June 20, 2014, for sale by Cubist Pharmaceuticals as tedizolid phosphate (SIVEXTRO®).
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeLevonorgestrel
go.drugbank.com/drugs/DB00367ApprovedInvestigationalLevonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy. … [L7823] In addition to the above uses, levonorgestrel is used as a component of long-term combination contraceptives.
Mixtures: CYCLO PROGYNOVA N 2MG/0.15, CYCLO PROGYNOVA N 2MG/0.15Products: ONIVE 1® 1.5 MG TABLETA, ONIVE 2® 0.75 MG TABLETASLarotrectinib
go.drugbank.com/drugs/DB14723ApprovedInvestigationalIt was notable for being the second tissue-agnostic chemotherapy ever approved by the FDA.[L4847]. On April 10, 2025, the FDA granted full drug approval.[L52805] … [L49821] Larotrectinib was granted accelerated approval by the FDA in November 2018 for the treatment of Trk-positive solid tumors.