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CTX110
go.drugbank.com/drugs/DB18626InvestigationalCTX110 is an allogeneic CRISPR/Cas9-mediated genetically modified CAR T cell therapy targeting CD19 antigen.
Synonyms: allogeneic CRISPR/Cas9-mediated genetically modified CAR T cells targeting CD19 antigenMetoclopramide
go.drugbank.com/drugs/DB01233ApprovedInvestigationalIt is available in the oral tablet form or in solution, and can also be administered through the intravenous route.[T683] Metoclopramide was initially approved by the FDA in 1980.[A184922] … It can also be used to prevent nausea or vomiting associated with chemotherapy or certain surgical or diagnostic procedures.
Mixtures: CLIFAR® GOTAS, PLASIL®ENZIMATICOCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, P-glycoprotein substratesPhenylketonuria (PKU)
go.drugbank.com/conditions/DBCOND0058086Synonyms: Hyperphenylalaninaemia, Type I, Hyperphenylalaninemia, type IObecabtagene autoleucel
go.drugbank.com/drugs/DB17362ApprovedInvestigational[A265040,A265045] It works by targeting B-cell-specific CD19 surface markers present on malignant B cells. … Obecabtagene autoleucel is an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy with a fast off-rate binding profile for CD19.
Categories: Genetically-modified Autologous T Cells, CD19-Directed Genetically Modified Autologous T-cell ImmunotherapiesSynonyms: A CHIMERIC ANTIGEN RECEPTOR (CAR) CONSISTING O, AUTOLOGOUS CD4+ AND CD8+ T CELLS, ENRICHED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMCS) OBTAINED BY APHERESIS TRANSDUCED EX VIVO WITH A NON-REPLICATING, SELF-INACTIVATING (SIN) LENTIVIRAL VECTOR, ENCODINGMeradimate
go.drugbank.com/drugs/DB11096Approved[T200] It is currently required to be named as meradimate in all FDA approved OTC products. Meradimate is approved by the FDA and Health Canada to be used as an ingredient in sunblocking products. … Meradimate, before known as menthyl anthranilate, is used in a maximal concentration of 5% in different products as a UV filter.
Mixtures: Body Armor Sun 'n Bug Block, Nutriance Uv Control Skin Protection Creme SPF 8Synonyms: Menthyl-O-aminobenzoatePostmenopausal Osteoporoses
go.drugbank.com/conditions/DBCOND0110643Drugs: EthinylestradiolSynonyms: Type I osteoporosisChoriocarcinoma
go.drugbank.com/conditions/DBCOND0017311Drugs: VincristineSynonyms: Choriocarcinoma, no ICD-O subtype, Choriocarcinoma, no International Classification of Diseases for Oncology subtypePeracetic acid
go.drugbank.com/drugs/DB14556InvestigationalA liquid that functions as a strong oxidizing agent. It has an acrid odor and is used as a disinfectant.
Categories: Compounds used in a research, industrial, or household settingProducts: Peraflu D, Pu Us PureLovastatin
go.drugbank.com/drugs/DB00227ApprovedInvestigational[A174580,A181409,A181535,A181538,A1793] Potency is thought to correlate to tissue permeability as the more lipophilic statins such as lovastatin are thought to enter endothelial cells by passive diffusion … were found in clinical studies to result in a 45.8% to 54.6% decrease in LDL cholesterol levels, while lovastatin has been found to have an average decrease in LDL-C of 25-40%.
Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsSynonyms: (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate, 2β,6α-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactoneEpidermal Growth Factor Receptor variant III (EGFRvIII) chimeric antigen receptor T cells
go.drugbank.com/drugs/DB18654InvestigationalSynonyms: EGFRvIII CAR-T, Autologous Chimeric Antigen Receptor (CAR) Modified Recombinant T Cells Targeting EGFRvIII