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Pipotiazine
go.drugbank.com/drugs/DB01621ApprovedInvestigationalWithdrawnHowever, it produces a high incidence of extra pyramidal reactions. It is used for the maintenance treatment of chronic non-agitated schizophrenic patients. … Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics.
Categories: Serotonin 5-HT1 Receptor Antagonists, Serotonin 5-HT2 Receptor AntagonistsProducts: PIPORTIL ® L-4SOLUCION INYECTABLE AL 2.5% (100 MG)., TRIPIPOT® SOLUCIÓN INYECTABLE 25 MG/MLLovastatin
go.drugbank.com/drugs/DB00227ApprovedInvestigational[A181087, A181406] Evidence has shown that even for low-risk individuals (with <10% risk of a major vascular event occurring within 5 years) statins cause a 20%-22% relative reduction in major cardiovascular … were found in clinical studies to result in a 45.8% to 54.6% decrease in LDL cholesterol levels, while lovastatin has been found to have an average decrease in LDL-C of 25-40%.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate, 2β,6α-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactoneInfliximab
go.drugbank.com/drugs/DB00065ApprovedInvestigationalalternative first-line therapies for that disorder [FDA Label]. … Infliximab is produced by a recombinant cell line cultured by continuous perfusion.
Synonyms: IMMUNOGLOBULIN G (HUMAN-MOUSE MONOCLONAL CA2 HEAVY CHAIN ANTI-HUMAN TUMOR NECROSIS FACTOR), DISULFIDE WITH HUMAN-MOUSE MONOCLONAL CA2 LIGHT CHAIN, DIMERProducts: INFLECTRA 100MG PLV F E KO, REMICADE 100MG PULV F E KOPyridostigmine
go.drugbank.com/drugs/DB00545ApprovedInvestigationalMyasthenia gravis is an autoimmune disease involving dysfunction at the neuromuscular junction, most commonly due to autoantibodies directed against the acetylcholine receptor (AChR), which results in … [A231009, A231014, L32413, L32418] Pyridostigmine was granted initial FDA approval on April 6, 1955, as an oral tablet.
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersInternational brands: Kalymin NMefenamic acid
go.drugbank.com/drugs/DB00784ApprovedIt is an inhibitor of cyclooxygenase.
Synonyms: N-(2,3-xylyl)-2-aminobenzoic acid, N-2,3-xylylanthranilic acidMixtures: แอนพัส 520Colistin
go.drugbank.com/drugs/DB00803ApprovedInvestigationalIt is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes.
Synonyms: Polymyxin EProducts: Poly-E Water Soluble Powder 750MIU/kg, APSASOL COLISTIN Powder 100 mg/gClomipramine
go.drugbank.com/drugs/DB01242ApprovedInvestigationalVet approvedThey contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or arousal, but may cause sedation. … The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission.
Categories: Serotonin 5-HT2 Receptor Antagonists, Serotonin 5-HT2A Receptor AntagonistsSynonyms: 3-(3-chloro-5H-dibenzo[b,F]azepin-5-yl)-N,N-dimethylpropan-1-amine, 3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamineBevacizumab
go.drugbank.com/drugs/DB00112ApprovedInvestigationalfor intravitreal injection, which received European Commission and MHRA marketing authorization in 2024 and FDA approval on July 24, 2026 for the treatment of wet AMD. … [A193272,A193275,L12648] Avastin was subsequently approved by Health Canada on March 24, 2010 and by the European Commission on April 21, 2021.
Products: ABXEDA E, ZIRABEV CONCENTRATE FOR SOLUTION FOR INFUSION 100 MG/4 MLDuloxetine
go.drugbank.com/drugs/DB00476ApprovedInvestigational[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. … Duloxetine continues to be investigated for the treatment of pain in cancer, surgery, and more.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsSynonyms: (3S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine