Mefenamic acid is an NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties.
- Mechanism
- Curator reviewed
Mefenamic acid binds the prostaglandin synthetase receptors COX-1 and COX-2, inhibiting the action of prostaglandin synthetase. As these receptors have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity, the symptoms of pain are temporarily reduced.
- Primary indication
- For the treatment of rheumatoid arthritis, osteoarthritis, dysmenorrhea, and mild to moderate pain, inflammation, and fever.Curator reviewed · 4 structured indications
- Formula / weight
- C15H15NO2 · 241.2851 g/mol (avg)
- First approval
- Canada, 1997 · United States, 1967
- Code names
- CI-473 · CN-35355 · INF-3355 · J2.344B · M01AG01
- Brand names
Resolves to
HYYBABOKPJLUIN-UHFFFAOYSA-NSMILESCC1=C(C)C(NC2=CC=CC=C2C(O)=O)=CC=C1What you can answer from here — as of September 23, 2026
Which drugs share a target with Mefenamic acid, and which of those have an active Phase 3 trial?
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