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Diltiazem
go.drugbank.com/drugs/DB00343ApprovedInvestigational[T28] Being a potent vasodilator, diltiazem is used clinically as an antihypertensive, anti-arrhythmic, and as an anti-anginal agent [L6289] for the management of cardiovascular conditions such as hypertension … Diltiazem is a benzothiazepine derivative with antihypertensive and vasodilating properties.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSynonyms: (+)-cis-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate esterSilodosin
go.drugbank.com/drugs/DB06207ApprovedInvestigationalSilodosin is available as oral capsules with common trade names Rapaflo and Urorec. It is indicated for the symptomatic treatment of benign prostatic hyperplasia in adults. … Silodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α<sub>1A</sub> subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesProducts: Ag-silodosin, SILODOSIN AL 4 MG HKPBrompheniramine
go.drugbank.com/drugs/DB00835ApprovedHistamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.
Synonyms: 2-(p-bromo-α-(2-dimethylaminoethyl)benzyl)pyridine, 1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropaneMixtures: Altidec A, Poly-Tussin ACArbutin
go.drugbank.com/drugs/DB11217ApprovedIt has also been used as an anti-infective for the urinary system as well as a diuretic [F43]. … Most commonly, it is an active ingredient in skincare and cosmetic products as a skin-lightening agent for the prevention of melanin formation in various skin conditions that involve cutaneous hyperpigmentation
Mixtures: Dr Young 2p Brightening UV Sun Block SPF50 PA, The Prestige BB SPF25 PA 2PlusSynonyms: p-hydroxyphenyl β-D-glucoside, p-hydroxyphenyl β-D-glucopyranosideSpironolactone
go.drugbank.com/drugs/DB00421ApprovedInvestigationalSpironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists.
Categories: P-glycoprotein inducers, Cytochrome P-450 CYP2C8 InhibitorsProducts: SPIRONOLACTON 100MG AAA PH, ALDACTONE ATenofovir disoproxil
go.drugbank.com/drugs/DB00300ApprovedInvestigationalTenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name _Viread_, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase … This drug is prescribed in combination with other drugs for the management of HIV infection as well as for Hepatitis B therapy. Tenofovir disoproxil was initially approved in 2001 [FDA label].
Mixtures: Ag-emtricitabine / Tenofovir Disoproxil FumarateCategories: P-glycoprotein inhibitors, P-glycoprotein substratesMethyl aminolevulinate
go.drugbank.com/drugs/DB00992ApprovedInvestigationalMethyl aminolevulinate is a prodrug that is metabolised to Protoporphyrin IX (a photosensitizer) used in photodynamic therapy.
Products: KRX Aesthetics PD-13 TherapyAmsacrine
go.drugbank.com/drugs/DB00276ApprovedInvestigationalWithdrawnAminoacridine derivative that is a potent intercalating antineoplastic agent.
International brands: AMSA P-DCategories: P-glycoprotein inhibitors, Compounds used in a research, industrial, or household settingRamipril
go.drugbank.com/drugs/DB00178ApprovedInvestigationalRamipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. … ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS).
Mixtures: RAMIPRIL HEXAL PL AM 5/5, RAMIPRIL HEXAL PL AM 5/5Products: Ag-ramipril, Ava-ramiprilDigoxin
go.drugbank.com/drugs/DB00390ApprovedInvestigational[A178234] Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. … They were one of the first to prescribe cardiac glycosides, according to ancient literature dating as early as the 1250s.[A178240]
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, P-glycoprotein inducersProducts: LANOXIN PG 62.5MCG TABLETS, LANOXIN-PG PAEDIATRIC/GERIATRIC TABLET 0.0625 mg