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Duloxetine
go.drugbank.com/drugs/DB00476ApprovedInvestigationalDuloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. … [A178741] Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder.
Products: Ag-duloxetine, DULOXETIN AL 20MG KMRVenlafaxine
go.drugbank.com/drugs/DB00285ApprovedInvestigationalVenlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). … [A252065] Venlafaxine has been used as a first-line treatment for MDD, GAD, social anxiety disorder, and panic disorder in Canada for many years.
Products: VENLAFAXINA ABC, VENLAFAXIN AL 75MG REKDiazepam
go.drugbank.com/drugs/DB00829ApprovedIllicitInvestigationalVet approvedThis current development is subsequently an important addition to the rescue therapy tool chest for patients with epilepsy [L5200]. … It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal
Products: DIAZEPAM ABC, DIAZEPAM ABZ 5MGBromocriptine
go.drugbank.com/drugs/DB01200ApprovedInvestigationalWithdrawnBromocriptine is also indicated for the management of signs and symptoms of Parkinsonian Syndrome, as well as the treatment of acromegaly. … Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity.
Products: BROMOCRIPTIN ABZ 2.5MG, AA PHARMA BROMOCRIPTINE TABLET 2.5 mgEnalapril
go.drugbank.com/drugs/DB00584ApprovedInvestigationalVet approvedIt was developed from a targeted research programmed using molecular modelling. … It is also found in a combination product containing [hydrochlorothiazide] that is used for the management of hypertension.
Mixtures: ENAPLUS AL 20MG/12.5MG TAB, ENAPLUS AL 20MG/12.5MG TABProducts: ENALAPRIL AL 5, ENALAPRIL AL 10Roxithromycin
go.drugbank.com/drugs/DB00778ApprovedInvestigationalWithdrawnIt is marketed in Australia as a treatment for respiratory tract, urinary and soft tissue infections. … Roxithromycin is a semi-synthethic macrolide antibiotic that is structurally and pharmacologically similar to [erythromycin], [azithromycin], or [clarithromycin].
International brands: Ai Luo Xin, Ao Ge ShenProducts: ROXITHROMYCIN ABZ 150MG, ROXITHROMYCIN ABZ 300MGDoxazosin
go.drugbank.com/drugs/DB00590ApprovedInvestigationalDoxazosin is an alpha-1 antagonist used for the treatment of benign prostatic hypertrophy (BPH) symptoms and hypertension. … [A180661] Because of its long-lasting effects, doxazosin can be administered once a day.[A180649] It is marketed by Pfizer and was initially approved by the FDA in 1990.[L7285]
Products: DOXAZOSIN AL 1, DOXAZOSIN AL 2Anagrelide
go.drugbank.com/drugs/DB00261ApprovedInvestigational[L14153] It is an oral imidazoquinazoline that was first approved for use in the US in 1997.[A214274] It appears to carry a better response rate than other thrombocythemia treatments (e.g. … Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms.
Categories: Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexProducts: ANAGRELID ABZ 1MG, ANAGRELID ABZ 0.5MGDiltiazem
go.drugbank.com/drugs/DB00343ApprovedInvestigational[T28] Being a potent vasodilator, diltiazem is used clinically as an antihypertensive, anti-arrhythmic, and as an anti-anginal agent [L6289] for the management of cardiovascular conditions such as hypertension … Diltiazem is a benzothiazepine derivative with antihypertensive and vasodilating properties.
Synonyms: (2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate, Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl esterInternational brands: Incoril AP