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Displaying results 8301 - 8310 of 10000 in total
  1. Drug

    Bicifadine

    go.drugbank.com/drugs/DB04889
    Investigational

    Bicifadine (DOV-220075) is a nonopioid analgesic. It is an inhibitor of both the norepinephrine and serotonin transporters and an NMDA antagonist with a non-narcotic profile. … Bicifadine was shown to have potent analgesic activity in vivo and was chosen for further development for the treatment of pain.

    Categories: Monoamine Oxidase A Substrates
  2. Drug

    Deoxyribonuclease I

    go.drugbank.com/drugs/DB16523
    Investigational

    Deoxyribonuclease I (DNase I) is a human enzyme responsible for the digestion of extracellular DNA7[A227723]. It is normally found in saliva, urine, pancreatic secretions, and blood[A227723]. … Currently, DNase I is being investigated against respiratory failure in COVID-19 in the clinical trial NCT04541979 (Aerosoliserat DNase for Treatment of Respiratory Failure in Severe COVID-19).

    Categories: Deoxyribonuclease I, antagonists & inhibitorsSynonyms: DNase I, Deoxyribonuclease I
  3. Drug

    Bemegride

    go.drugbank.com/drugs/DB13740
    Experimental

    Bemegride is a CNS stimulant that is used to induce convulsions in experimental animals. It has also been used as a respiratory stimulant and in the treatment of barbiturate overdose.

  4. Drug

    mRNA-3705

    go.drugbank.com/drugs/DB17668
    Investigational

    mRNA-3705 is an investigational mRNA encoding methylmalonic CoA mutase (MUT) enzyme. Developed by Moderna TX Inc., it is being investigated for the treatment of methylmalonic academia.[A258843]

  5. Drug

    Efdoralprin alfa

    go.drugbank.com/drugs/DB18384
    Investigational

    Efdoralprin alfa is a recombinant human alpha-1 antitrypsin (AAT)-Fc fusion protein.[L54928] It is being investigated as a restorative therapy in adults with AATD emphysema.[L54928]

  6. Drug

    Butyrylthiocholine

    go.drugbank.com/drugs/DB04250
    Experimental

    A sulfur-containing analog of butyrylcholine which is hydrolyzed by butyrylcholinesterase to butyrate and thiocholine. It is used as a reagent in the determination of butyrylcholinesterase activity.

  7. Drug

    D-Treitol

    go.drugbank.com/drugs/DB03278
    Experimental

    A four-carbon sugar that is found in algae, fungi, and lichens. It is twice as sweet as sucrose and can be used as a coronary vasodilator. [PubChem]

  8. Drug

    Dihydroxyacetone

    go.drugbank.com/drugs/DB01775
    Experimental

    It is readily phosphorylated to dihydroxyacetone phosphate by triokinase in erythrocytes. In combination with naphthoquinones it acts as a sunscreening agent. [PubChem] … A ketotriose compound. Its addition to blood preservation solutions results in better maintenance of 2,3-diphosphoglycerate levels during storage.

  9. Drug

    Surotomycin

    go.drugbank.com/drugs/DB12076
    Investigational

    Surotomycin has a fourfold greater in vitro potency than vancomycin against C. … It is a benzenebutanoic acid derivative patented by Cubist Pharmaceuticals, Inc. as antibacterial agents for the treatment of Gram-positive infections.

  10. Drug

    Cagrilintide

    go.drugbank.com/drugs/DB18887
    Investigational

    Cagrilintide is under investigation in clinical trial NCT06221969 (A Research Study to See How Much Cagrisema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated … With Metformin With or Without an SGLT2 Inhibitor).

    Synonyms: L-Prolinamide, N-(19-carboxy-1-oxononadecyl)-L-γ-glutamyl-L-lysyl-L-cysteinyl-L-asparaginyl-L-threonyl-L-alanyl-L-threonyl-L-cysteinyl-L-alanyl-L-threonyl-L-glutaminyl-L-arginyl-L-leucyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-L-leucyl-L-arginyl-L-histidyl