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Displaying results 8311 - 8320 of 10000 in total
  1. Drug

    Avapritinib

    go.drugbank.com/drugs/DB15233
    ApprovedInvestigational

    [A189339,L40363] It is one of the first medications available for the treatment of multidrug resistant cancers.[A189327] Avapritinib shares a similar mechanism with [ripretinib]. … Avapritinib, or BLU-285,[A189327] is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal

    Categories: MATE 2-K Inhibitors, MATE 1 Inhibitors
  2. Drug

    Di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone

    go.drugbank.com/drugs/DB15235
    Investigational

    Di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone is under investigation in clinical trial NCT02688101 (Dose-finding and Pharmacokinetic Study of DpC, Administered Orally to Patients With Advanced

    Categories: Heterocyclic Compounds, 1-RingSynonyms: Di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone
  3. Drug

    Elezanumab

    go.drugbank.com/drugs/DB15240
    Investigational

    Elezanumab is under investigation in clinical trial NCT03737812 (A Study to Assess the Safety and Efficacy of Elezanumab When Added to Standard of Care in Progressive Forms of Multiple Sclerosis).

  4. Drug

    Methylsamidorphan

    go.drugbank.com/drugs/DB15241
    Investigational

    Methylsamidorphan is under investigation in clinical trial NCT01418092 (ALK37-007: Evaluation of Safety and Efficacy of ALKS 37 (RDC-1036) in Adults With Opioid-induced Constipation (OIC)).

  5. Drug

    Salvianolic acid A

    go.drugbank.com/drugs/DB15246
    Investigational

    Salvianolic acid A is under investigation in clinical trial NCT03908242 (Phase I Study of Continuous Administration of Salvianolic Acid A Tablet).

    Synonyms: Salvianolic acid A
  6. Drug

    Vorolanib

    go.drugbank.com/drugs/DB15247
    Investigational

    Vorolanib is under investigation in clinical trial NCT03904719 (CM082 and JS001 in Patients With Advanced Small-cell Lung Cancer (SCLC)).

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring
  7. Drug

    MK-6325

    go.drugbank.com/drugs/DB15249
    Investigational

    MK-6325 is under investigation in clinical trial NCT01329913 (Safety, Pharmacokinetics, and Pharmacodynamics of MK-6325 in Hepatitis C Virus (HCV) Infections (MK-6325-003)).

  8. Drug

    Nemolizumab

    go.drugbank.com/drugs/DB15252
    ApprovedInvestigational

    Nemolizumab is a humanized monoclonal modified immunoglobulin 2 (IgG2) antibody directed against interleukin-31 receptor alpha (IL-31RA),[L51159] which is an endogenous cytokine implicated in the pathophysiology

    Synonyms: )-IGHJ5*01) [8.8.14] (1-121) -Homo sapiens IGHG2*0, Immunoglobulin G2, anti-(interleukin 31 receptor A) (human-Mus musculus monoclonal CIM331 γ-chain), disulfide with human-Mus musculus monoclonal CIM331 κ-chain, dimer
  9. Drug

    Imlifidase

    go.drugbank.com/drugs/DB15258
    ApprovedInvestigational

    Chronic kidney disease (CKD) is a progressive and irreversible disease that represents a significant burden for both the individual and healthcare system at large. … [A225836,A225921] Imlifidase is a cysteine protease and eliminates Fc-dependent effector functions such as CDC and ADCC by cleaving the heavy chains of human immunoglobulin G (IgG) antibodies.

  10. Drug

    VB-201

    go.drugbank.com/drugs/DB15259
    Investigational

    VB-201 is under investigation in clinical trial NCT01001468 (Study to Assess VB-201 in Patients With Psoriasis).