Search
Everolimus
go.drugbank.com/drugs/DB01590ApprovedInvestigationalIn a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein. … Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: 40-O-(2-hydroxyethyl)-rapamycin, 42-O-(2-Hydroxyethyl)rapamycinTiaprofenic acid
go.drugbank.com/drugs/DB01600ApprovedTiaprofenic acid is a non-steroidal anti-inflammatory drug employed in the treatment of pain, particularly arthritis pain.
Categories: Non COX-2 selective NSAIDSSynonyms: 2-(5-Benzyl-2-thienyl)propionsäure, 2-(5-Benzoyl-thiophen-2-yl)-propionic acidValganciclovir
go.drugbank.com/drugs/DB01610ApprovedInvestigationalAs the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases.
Categories: Heterocyclic Compounds, 2-RingProducts: GANOCIP®, TRASGARIV®Aceprometazine
go.drugbank.com/drugs/DB01615ExperimentalAceprometazine is a is a drug with neuroleptic and anti-histamine properties.
Categories: Heterocyclic Compounds, 3-RingSynonyms: 10-(2-(Dimethylamino)propyl)phenothiazin-2-yl methyl ketoneMolindone
go.drugbank.com/drugs/DB01618ApprovedMolindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors.
Categories: Heterocyclic Compounds, 2-Ring, Serotonin 5-HT1 Receptor AntagonistsThioproperazine
go.drugbank.com/drugs/DB01622ApprovedThioproperazine is a potent neuroleptic with antipsychotic properties. … Thioproperazine has a marked cataleptic and antiapomorphine activity associated with relatively slight sedative, hypothermic and spasmolytic effects.
Categories: Heterocyclic Compounds, 3-Ring, Adrenergic alpha-1 Receptor AntagonistsSynonyms: N,N-Dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine-2-sulfonamide, N,N-Dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine-2-sulfonamideIsopropamide
go.drugbank.com/drugs/DB01625ApprovedVet approvedWithdrawnIsopropamide iodide is a long-acting quaternary anticholinergic drug. It is used in the treatment of peptic ulcer and other gastrointestinal disorders marked by hyperacidity and hypermotility.
Mixtures: Stelabid No 2, Stelabid No 1Etoricoxib
go.drugbank.com/drugs/DB01628ApprovedInvestigationalWithdrawnEtoricoxib is a new COX-2 selective inhibitor. … Like any other COX-2 selective inhibitor, Etoricoxib selectively inhibits isoform 2 of cyclo-oxigenase enzyme (COX-2) to reduce the generation of prostaglandins (PGs) from arachidonic acid.
Categories: COX-2 Inhibitors, Cytochrome P-450 SubstratesSynonyms: 5-chloro-2-(6-methylpyridin-3-yl)-3-(4-(methylsulfonyl)phenyl)pyridine, 5-Chloro-3-(4-methanesulfonyl-phenyl)-6'-methyl-[2,3']bipyridinyl4-hydroxybenzoyl-CoA
go.drugbank.com/drugs/DB01652ExperimentalCategories: Thioesters of coenzyme A, Heterocyclic Compounds, 2-RingSynonyms: 4-hydroxybenzoyl coenzyme A, 4-hydroxybenzoyl-coenzyme ARoflumilast
go.drugbank.com/drugs/DB01656ApprovedInvestigationalRoflumilast is a highly selective phosphodiesterase-4 (PDE4) inhibitor. … [A251385] PDE4 is a major cyclic-3',5′-adenosinemonophosphate (cyclic AMP, cAMP)-metabolizing enzyme [L37564] expressed on nearly all immune and pro-inflammatory cells, in addition to structural cells
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingProducts: DAXAS®