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Displaying results 8401 - 8410 of 10000 in total
  1. Drug

    Dactinomycin

    go.drugbank.com/drugs/DB00970
    ApprovedInvestigational

    A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. … It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release.

    Synonyms: ACTINOMYCIN I1, Actinomycin IVProducts: K. U. DACTINOMYCIN FOR INJECTION 0.5 mg/vial
  2. Drug

    5-methoxy-N,N-dimethyltryptamine

    go.drugbank.com/drugs/DB14010
    IllicitInvestigational

    It is found in a wide variety of plant species, and a single psychoactive toad species, the Colorado River toad. … This drug, as well as [dimethyltryptamine] and [bufotenin], have been registered to be used in South America in religious and spiritual rituals.

    Categories: Serotonin Receptor Agonists, Serotonin 5-HT1 Receptor Agonists
  3. Drug

    Bicuculline

    go.drugbank.com/drugs/DB11562
    Experimental

    It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species. … Bicuculline is a light-sensitive competitive antagonist of GABAA receptors.

    Categories: GABA-A Receptor Antagonists
  4. Drug

    Ulixertinib

    go.drugbank.com/drugs/DB13930
    Investigational

    It is currently in clinical trials for the treatment of a wide range of tumors. … Ulixertinib is a a novel, reversible, ATP-competitive ERK1/2 inhibitor with high potency and ERK1/2 selectivity [A31474].

  5. Drug

    Ontuxizumab

    go.drugbank.com/drugs/DB16270
    Investigational

    It is under investigation in clinical trial NCT01574716 (Sarcoma Study of Morab-004 Utilization: Research and Clinical Evaluation). … Ontuxizumab is a humanized monoclonal antibody that targets endosialin or tumour endothelial marker 1 (TEM-1).

  6. Drug

    Melogliptin

    go.drugbank.com/drugs/DB20789
    Experimental

    Melogliptin is a small molecule drug. The usage of the INN stem '-gliptin' in the name indicates that Melogliptin is a dipeptidyl aminopeptidase-IV inhibitor.

  7. Drug

    Garvagliptin

    go.drugbank.com/drugs/DB21280
    Experimental

    Garvagliptin is a small molecule drug. The usage of the INN stem '-gliptin' in the name indicates that Garvagliptin is a dipeptidyl aminopeptidase-IV inhibitor.

  8. Drug

    Dipraglurant

    go.drugbank.com/drugs/DB12733
    Investigational

    Dipraglurant has been used in trials studying the treatment of Parkinson's Disease. It is a metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator (NAM).

  9. Drug

    Trifluoroethanol

    go.drugbank.com/drugs/DB03226
    Experimental

    It is also used in various pharmaceutical, chemical and engineering applications.

  10. Drug

    Nemtabrutinib

    go.drugbank.com/drugs/DB18866
    Investigational

    Nemtabrutinib is under investigation in clinical trial NCT05624554 (A Study of Nemtabrutinib vs Chemoimmunotherapy for Participants With Previously Untreated Chronic Lymphocytic Leukemia/small Lymphocytic … Lymphoma (CLL/SLL) Without TP53 Aberrations (MK-1026-008, BELLWAVE-008)).