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Disulfiram
go.drugbank.com/drugs/DB00822ApprovedInvestigationalA carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol.
Synonyms: N,N,N',N'-tetraethylthiuram disulfide, 1,1'-dithiobis(N,N-diethylthioformamide)Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesCinoxacin
go.drugbank.com/drugs/DB00827ApprovedWithdrawnSynthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections.
Synonyms: 1-ethyl-6,7-methylenedioxy-4(1H)-oxocinnoline-3-carboxylic acid, 5-Ethyl-8-oxo-5,8-dihydro-1,3-dioxa-5,6-diaza-cyclopenta[b]naphthalene-7-carboxylic acidCategories: Heterocyclic Compounds, 3-Ring, Cytochrome P-450 CYP1A2 InhibitorsFosfomycin
go.drugbank.com/drugs/DB00828ApprovedInvestigational[A230348] Due to its ease of administration as a single 3-gram oral dose and desirable safety profile, fosfomycin has largely become a first-line therapeutic option for the treatment of uncomplicated … [A230348] In terms of chemical structure, fosfomycin is a phosphoenolpyruvate analog and contains a phosphonic group and an epoxide ring.
Synonyms: L-cis-1,2-epoxypropylphosphonic acid, (2R-cis)-(3-Methyloxiranyl)phosphonic acidProducts: FOSTREN® 3 G, ACECNOU® 2 GDiazepam
go.drugbank.com/drugs/DB00829ApprovedIllicitInvestigationalVet approvedA benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. … (From Martindale, The Extra Pharmacopoeia, 30th ed, p589) Given diazepam's storied history as a commonly used and effective medication for a variety of indications, contemporary advancements in the
Synonyms: 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one, NRL-1Mixtures: Gabavale-5Trifluoperazine
go.drugbank.com/drugs/DB00831ApprovedA phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic.
Synonyms: 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine, trifluoromethyl-10-(3'-(1-methyl-4-piperazinyl)propyl)phenothiazineMixtures: Stelabid No 2, Stelabid No 1Mifepristone
go.drugbank.com/drugs/DB00834ApprovedInvestigationalThe two marketed forms of mifepristone are Mifeprex® (mifepristone 200mg) and Korlym™ (mifepristone 300mg). Currently under investigation for use in psychotic depression (phase 3 trials). … Mifepristone is a progestational and glucocorticoid hormone antagonist.
Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsNalbuphine
go.drugbank.com/drugs/DB00844ApprovedInvestigationalA narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. … Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States.
Synonyms: N-cyclobutylmethyl-4,5α-epoxy-3,6α,14-morphinantriolCategories: Heterocyclic Compounds with 4 or More RingsClofazimine
go.drugbank.com/drugs/DB00845ApprovedInvestigationalWithdrawnClofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. … It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloration of the skin and bodily fluids.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: CLOFZIMIN® 100 MGLevamisole
go.drugbank.com/drugs/DB00848ApprovedInvestigationalVet approvedWithdrawn[A178123] Interestingly, levamisole has been found as an adulterant in cocaine and can lead to a variety of adverse effects in individuals using this drug.[A178120]
Categories: Heterocyclic Compounds, 1-RingProducts: PVP- LEVAMISOLE POUR-ON SOLUTION 20 %w/v, PARAKS 40 MG TABLET, 6 ADETLevorphanol
go.drugbank.com/drugs/DB00854ApprovedA narcotic analgesic that may be habit-forming. It is nearly as effective orally as by injection.
Categories: Heterocyclic Compounds with 4 or More Rings