Levorphanol

DB00854ApprovedSmall moleculeOpioid Agonist

Levorphanol is an opioid analgesic used to treat moderate to severe pain. A narcotic analgesic that may be habit-forming.

Mechanism: Like other mu-agonist opioids it is believed to act at receptors in the periventricular and periaqueductal gray matter in both the brain and spinal cord to alter the transmission and perception of pain.
Curator reviewed
Primary indication: For the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate.Curator reviewed · 2 structured indications
Formula / weight: C₁₇H₂₃NO · 257.3706 g/mol (avg)
First approval: United States, 1953
Code names: Dea No. 9220 · Dea No. 9733 · IDS-NL-007 · RO 1-5431

Resolves to

Compound

UNII27618J1N2XCAS77-07-6ChEMBLCHEMBL592ChEBI6444PubChem5359272KEGGD08123

Clinical / RWD

RxNorm6378PharmGKBPA164744368

Structure

InChIKeyJAQUASYNZVUNQP-USXIJHARSA-NSMILES[H][C@@]12CCCC[C@@]11CCN(C)[C@@H]2CC2=C1C=C(O)C=C2

Targets

P35372OPRM1P41143OPRD1P41145OPRK1

What you can answer from here — as of September 23, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

921Drug interactionsStructured to mechanism, not free text

2Clinical trialsPhase, status and sponsor resolved per trial

2Structured indicationsCondition, population, route and combination as fields, not prose

19Marketed productsAcross 1 country and 11 labellers

7+ReferencesStructured and connected to the statements they support

Which drugs share a target with Levorphanol, and which of those have an active Phase 3 trial?

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