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Carbidopa
go.drugbank.com/drugs/DB00190ApprovedInvestigationalCarbidopa presents a chemical denomination of N-amino-alpha-methyl-3-hydroxy-L-tyrosine monohydrate. … An individual formulation containing solely carbidopa was generated to treat nausea in patients where the combination therapy [levodopa]/carbidopa is not efficient reducing nausea.
Mixtures: Ag-levocarb, Ag-levocarbBosutinib
go.drugbank.com/drugs/DB06616ApprovedInvestigational(Ph+) CML. … [A6901,A17961] Bosutinib was first approved by the FDA in 2012 for the treatment of adult chronic, accelerated, or blast-phase Ph+ CML with resistance or intolerance to prior therapy.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexScopolamine
go.drugbank.com/drugs/DB00747ApprovedInvestigational[A228758, L31578] Due to its dose-dependent adverse effects, scopolamine was the first drug to be offered commercially as a transdermal delivery system, Scopoderm TTS®, in 1981. … [A228773, L31578] Scopolamine was first approved by the FDA on December 31, 1979, and is currently available as both oral tablets and a transdermal delivery system.[L31578]
Mixtures: PB Hyos, Re-PB HyosCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesAntihemophilic factor human
go.drugbank.com/drugs/DB13192ApprovedInvestigationalAntihemophilic factor human, also known as Coagulation Factor VIII or Anti-Hemophilic Factor (AHF), is a non-recombinant, lyophilized concentrate of coagulation factor VIII, an endogenous protein and essential … Activation of Factor IX leads to a cascade of signals that results in activation of Factor X, which then results in the conversion of prothrombin to thrombin, and as a result, leads to the conversion of
Mixtures: IMMUNATE 500 IU/375 IU IV INFUZYONLUK TOZ ICEREN FLAKON, 1 ADET, IMMUNATE 1000 IU/750 IU IV INFUZYONLUK TOZ ICEREN FLAKON, 1 ADETCategories: Hemophilia APromazine
go.drugbank.com/drugs/DB00420ApprovedVet approvedWithdrawnA phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsMoxetumomab pasudotox
go.drugbank.com/drugs/DB12688ApprovedInvestigationalThis antibody was used to generate a recombinant immunotoxin in which a stabilized Fv segment by a disulfide bond is fused to the _Pseudomonas_ exotoxin A (PE38) which does not have the cell-binding portion … [A38864] MxP appears as an improved form of BL22 by the mutation of the Fv region and the antibody phage-displayed. As well the residues SSY in the heavy chain are mutated to THW.
Rosiglitazone
go.drugbank.com/drugs/DB00412ApprovedInvestigationalThis is the subject of a clinical trial currently underway. … It is marketed by the pharmaceutical company GlaxoSmithKline as a stand-alone drug (Avandia) and in combination with metformin (Avandamet) or with glimepiride (Avandaryl).
Synonyms: (±)-5-[p-[2-(methyl-2-pyridylamino)ethoxy]benzyl]-2,4-thiazolidinedioneInternational brands: Sheng AoPrednisone
go.drugbank.com/drugs/DB00635ApprovedInvestigationalVet approvedA synthetic anti-inflammatory glucocorticoid derived from [cortisone].[A187463] It is biologically inert and converted to [prednisolone] in the liver.
Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsProducts: Prednisone D/P, P- Pack Prednisone 20mg, 7- Day Tapering Dose PackUbidecarenone
go.drugbank.com/drugs/DB09270ApprovedInvestigationalNutraceutical[L1062] Ubidecarenone is sold as a dietary supplement and is not FDA approved as a drug - it is not meant to treat, cure or prevent any disease. … [A7874] It is a powerful antioxidant, a lipid-soluble and essential cofactor in mitochondrial oxidative phosphorylation.
Mixtures: Protect Cardio AF, Folika-VCategories: P-glycoprotein substratesOmega-3-carboxylic acids
go.drugbank.com/drugs/DB09568ApprovedWithdrawnThe increased bioavailability is explained because OM3-CA is found in a form of polyunsaturated free fatty acids as opposed to other products whose form is as ethyl esters. … It is a complex mixture of the free fatty acids form containing eicosapentaenoic acid and docosahexaenoic acid as the most abundant species found in a proportion of 55% and 20% respectively.