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Mosedipimod
go.drugbank.com/drugs/DB12592InvestigationalMosedipimod has been used in trials studying the supportive care and treatment of Chemotherapy-induced Neutropenia.
Synonyms: 1-Palmitoyl-2-linoleoyl-3-acetyl-rac-glycerolNerinetide
go.drugbank.com/drugs/DB12595InvestigationalNa 1 is under investigation in clinical trial NCT00728182 (Evaluating Neuroprotection in Aneurysm Coiling Therapy).
Synonyms: L-TYROSYLGLYCYL-L-ARGINYL-L-LYSYL-L-LYSYL-L-ARGINYL-L-ARGINYL-L-GLUTAMINYL-L-ARGINYL-L-ARGINYL-L-ARGINYL-L-LYSYL-L-LEUCYL-L-SERYL-L-SERYL-L-ISOLEUCYL-L-.ALPHA.-GLUTAMYL-L-SERYL-L-.ALPHA., L-VALINE, L-TYROSYLGLYCYL-L-ARGINYL-L-LYSYL-L-LYSYL-L-ARGINYL-L-ARGINYL-L-GLUTAMINYL-L-ARGINYL-L-ARGINYL-L-ARGINYL-L-LYSYL-L-LEUCYL-L-SERYL-L-SERYL-L-ISOLEUCYL-L-.ALPHA.-GLUTAMYL-L-SERYL-L-.ALPHA.Asciminib
go.drugbank.com/drugs/DB12597ApprovedInvestigationalMore specifically, it is an inhibitor of the ABL1 kinase activity of the BCR-ABL1 fusion protein[L38995] which serves as a driver of CML proliferation in most patients with the disease. … [L39005] It has also shown benefit in Ph+ CML with the T315I mutation, which produces a mutant BCR-ABL1 which is typically treatment-resistant as compared to wild-type BCR-ABL1.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSisomicin
go.drugbank.com/drugs/DB12604InvestigationalSisomicin has been used in trials studying the treatment of Pyoderma.
Synonyms: (2S-CIS)-4-O-(3-AMINO-6-(AMINOMETHYL)-3,4-DIHYDRO-2H-PYRAN-2-YL)-2-DEOXY-6-O-(3-DEOXY-4-C-METHYL-3-(METHYLAMINO)-.BETA.-L-ARABINOPYRANOSYL)-D-STREPTAMINE, O-3-DEOXY-4-C-METHYL-3-(METHYLAMINO)-.BETA-L-ARABINOPYRANOSYL-(1->4)-O-(2,6-DIAMINO-2,3,4,6-TETRADEOXY-.ALPHA.-D-GLYCERO-HEX-4-ENOPYRANOSYL-(1->6))-2-DEOXY-L-STREPTAMINECategories: Drugs that are Mainly Renally Excreted with a Narrow Therapeutic IndexEtripamil
go.drugbank.com/drugs/DB12605ApprovedInvestigationalEtripamil is a nondihydropyridine, L-type calcium channel blocker.[A275238, L54728] It is a fast-acting drug with a short duration of action.
Categories: MATE 1 Inhibitors, P-glycoprotein inhibitorsSynonyms: Benzoic acid, 3-[2-[[(4S)-4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl]methylamino]ethyl]-, methyl ester, Methyl 3-[2-[[(4S)-4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl]methylamino]ethyl]benzoateNetivudine
go.drugbank.com/drugs/DB12606InvestigationalNetivudine has been used in trials studying the treatment of Chickenpox and HIV Infections.
Categories: Heterocyclic Compounds, 1-RingDavunetide
go.drugbank.com/drugs/DB12613InvestigationalDavunetide is derived from a naturally occurring neuroprotective brain protein known as activity dependent neuroprotective protein. … Davunetide is the first drug to improve memory performance by impacting the mechanisms that lead to physical damage in the brain caused by neurofibrillary tangles, one of the two established pathological
Plazomicin
go.drugbank.com/drugs/DB12615ApprovedIt is marketed as Zemdri and is administered via once-daily intravenous infusion. … The structure of plazomicin was established via appending hydroxylaminobutyric acid to [DB12604] at position 1 and 2-hydroxyethyl group at position 6' [A33942].
Categories: MATE 1 Inhibitors, MATE 2 InhibitorsST-101
go.drugbank.com/drugs/DB12621InvestigationalST-101 is a small peptide antagonist of C/EBPβ and T-type calcium channel activator. ST101 has been used in trials studying the treatment of Essential Tremor and Alzheimer's Disease.[A260411]
Synonyms: ST-101 (D-AMINO ACID PEPTIDE), D-Arginine, D-valyl-D-alanyl-D-α-glutamyl-D-alanyl-D-arginyl-D-α-glutamyl-D-α-glutamyl-D-leucyl-D-α-glutamyl-D-arginyl-D-leucyl-D-α-glutamyl-D-alanyl-D-arginyl-D-leucylglycyl-D-glutaminyl-D-alanyl-D-arginylglycyl-D-α-glutamyl-D-leucyl-D-lysyl-D-lysMethyl-D9-choline
go.drugbank.com/drugs/DB12628InvestigationalMethyl-D9-choline is under investigation in clinical trial NCT01807910 (ER Stress in NAFLD).