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Tavapadon
go.drugbank.com/drugs/DB14899InvestigationalTavapadon is under investigation in clinical trial NCT02262767 (A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of PF-06649751 Co-administered With Trimethobenzamide Hydrochloride
Pimasertib
go.drugbank.com/drugs/DB14904InvestigationalPimasertib is under investigation in clinical trial NCT01378377 (Combination Trial of Pimasertib (MSC1936369B) With Temsirolimus).
Synonyms: N-[(2S)-2,3-dihydroxypropyl]-3-(2-fluoro-4-iodoanilino)pyridine-4-carboxamideCategories: Heterocyclic Compounds, 1-RingAbrocitinib
go.drugbank.com/drugs/DB14973ApprovedInvestigationalAbrocitinib is an oral small-molecule inhibitor of Janus kinase 1 (JAK1). … [L39774] The Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signalling pathway plays a central role in the pathogenesis of a variety of autoimmune and inflammatory diseases,
Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsProducts: CIBINQO® 100MG, CIBINQO® 50 MGRelacorilant
go.drugbank.com/drugs/DB14976ApprovedInvestigationalRelacorilant is a first-in-class, selective glucocorticoid receptor antagonist. … Originally investigated to manage the metabolic and endocrinologic complications of hypercortisolism, such as Cushing’s syndrome, its clinical utility has pivoted toward oncology as a potent sensitizing
Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 CYP2C8 InducersAZD-6482
go.drugbank.com/drugs/DB14980InvestigationalAZD-6482 is under investigation in clinical trial NCT00688714 (Study to Investigate Safety and Tolerability of a Single Dose of AZD6482).
Categories: Heterocyclic Compounds, 1-Ring, Class Ia Phosphatidylinositol 3-Kinase, antagonists & inhibitorsDifamilast
go.drugbank.com/drugs/DB14987ApprovedInvestigational[A275420] Difamilast is a selective PDE4 inhibitor and the inhibition of phosphodiesterase-4 (PDE4) reduces proinflammatory mediators and cytokines in atopic dermatitis. … [L56052, A275420] This skin disease occurs most frequently in children and can have an onset as early as within the first 2 years of life.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InducersSynonyms: 地法米司特Aprocitentan
go.drugbank.com/drugs/DB15059ApprovedInvestigationalAprocitentan is a dual antagonist of endothelin receptors A and B used for treatment-resistant hypertension. It is the active metabolite of [macitentan]. … blocker, and a diuretic at maximally tolerated doses.
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP2C18 InhibitorsRO-6870810
go.drugbank.com/drugs/DB15151InvestigationalRO-6870810 is under investigation in clinical trial NCT02308761 (A Study of RO6870810/TEN-010 in Participants With Acute Myeloid Leukemia and Myelodysplastic Syndrome).
Categories: Heterocyclic Compounds, 1-RingSynonyms: 2-[(4S)-6-(4-chlorophenyl)-1,7,8-trimethylthiophenol[3,2-f]1,2,4-triazolo[4,3-a]1,4-diazepin-4-yl]-N-[3-(4-methylpiperazinyl)propyl]acetamide, 6H-THIENO(3,2-F)(1,2,4)TRIAZOLO(4,3-A)(1,4)DIAZEPINE-6-ACETAMIDE, 4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-N-(3-(4-METHYL-1-PIPERAZINYL)PROPYL)-, (6S)-Evobrutinib
go.drugbank.com/drugs/DB15170InvestigationalEvobrutinib is under investigation in clinical trial NCT03934502 (Effect of Meal Composition and Timing on Evobrutinib Bioavailability).
Categories: Heterocyclic Compounds, 1-RingPaxalisib
go.drugbank.com/drugs/DB15186InvestigationalGDC-0084 is under investigation in clinical trial NCT03696355 (Study of GDC-0084 in Pediatric Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma or Diffuse Midline Gliomas).
Synonyms: 5-(6,6-dimethyl-4-morpholino-8,9-dihydro-6H-[1,4]oxazino[3,4-e]purin-2-yl)pyrimidin-2-amineCategories: Heterocyclic Compounds, 1-Ring