Paxalisib

DB15186InvestigationalSmall molecule

GDC-0084 is under investigation in clinical trial NCT03696355 (Study of GDC-0084 in Pediatric Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma or Diffuse Midline Gliomas).

Chemical structure of Paxalisib
Formula / weight
C18H22N8O2 · 382.428 g/mol (avg)
Code names
G-02441729 · GDC-0084 · SIM-0395

Resolves to

Compound
UNIIP5DKZ70636CAS1382979-44-3ChEMBLCHEMBL3813842
Structure
InChIKeyLGWACEZVCMBSKW-UHFFFAOYSA-NSMILESCC1(C)OCCN2C1=NC1=C(N=C(N=C21)C1=CN=C(N)N=C1)N1CCOCC1
Targets
P48736PIK3CG

What you can answer from here — as of September 13, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
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15Clinical trialsPhase, status and sponsor resolved per trial
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3+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Paxalisib, and which of those have an active Phase 3 trial?

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