GDC-0084

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name: GDC-0084
DrugBank Accession Number: DB15186
Background: GDC-0084 is under investigation in clinical trial NCT03696355 (Study of GDC-0084 in Pediatric Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma or Diffuse Midline Gliomas).
Type: Small Molecule
Groups: Investigational
Structure: 3D
MOL SDF 3D-SDF PDB SMILES InChI

Similar Structures
Structure for GDC-0084 (DB15186)
Synonyms: Not Available

Indication: Not Available
Reduce drug development failure rates
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Pharmacodynamics: Not Available
Mechanism of action: Not Available
Absorption: Not Available
Volume of distribution: Not Available
Protein binding: Not Available
Metabolism: Not Available
Route of elimination: Not Available
Half-life: Not Available
Clearance: Not Available
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Toxicity: Not Available
Pathways: Not Available
Pharmacogenomic Effects/ADRs: Not Available

Drug Interactions: This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions: Not Available

UNII: P5DKZ70636
CAS number: 1382979-44-3
InChI Key: LGWACEZVCMBSKW-UHFFFAOYSA-N
InChI: InChI=1S/C18H22N8O2/c1-18(2)16-22-12-14(25-3-6-27-7-4-25)23-13(11-9-20-17(19)21-10-11)24-15(12)26(16)5-8-28-18/h9-10H,3-8H2,1-2H3,(H2,19,20,21)
IUPAC Name: 5-[6,6-dimethyl-4-(morpholin-4-yl)-6H,8H,9H-[1,4]oxazino[3,4-h]purin-2-yl]pyrimidin-2-amine
SMILES: CC1(C)OCCN2C1=NC1=C(N=C(N=C21)C1=CN=C(N)N=C1)N1CCOCC1

General References

Not Available

External Links

Clinical Trials

Phase	Status	Purpose	Conditions	Count
2	Active Not Recruiting	Treatment	Glioblastoma, Adult	1
2	Recruiting	Treatment	Breast Cancer	1
2	Recruiting	Treatment	Diffuse Intrinsic Pontine Gliomas (DIPG) / Diffuse Midline Glioma, H3 K27M-Mutant / Recurrent Diffuse Intrinsic Pontine Glioma / Recurrent Diffuse Midline Glioma, H3 K27M-Mutant / Recurrent WHO Grade III Glioma / WHO Grade III Glioma	1
2	Recruiting	Treatment	Non-Hodgkin Lymphoma of Extranodal Site / Primary Central Nervous System Lymphoma (PCNSL)	1
2, 3	Recruiting	Treatment	Glioblastoma Multiforme (GBM)	1
1	Active Not Recruiting	Treatment	Brain and Central Nervous System Tumors	1
1	Completed	Treatment	Glioblastoma, Glioma	1
1	Recruiting	Treatment	Leptomeningeal Metastasis / Tumors Metastatic to Brain	1

State

Not Available

Experimental Properties

Not Available

Predicted Properties

Predicted ADMET Features

Not Available

Drug created at May 20, 2019 14:57 / Updated at June 12, 2020 16:53