NAV

Paxalisib

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Paxalisib
DrugBank Accession Number
DB15186
Background

GDC-0084 is under investigation in clinical trial NCT03696355 (Study of GDC-0084 in Pediatric Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma or Diffuse Midline Gliomas).

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 382.428
Monoisotopic: 382.18657198
Chemical Formula
C18H22N8O2
Synonyms
  • 5-(6,6-dimethyl-4-morpholino-8,9-dihydro-6H-[1,4]oxazino[3,4-e]purin-2-yl)pyrimidin-2-amine
External IDs
  • G-02441729
  • G02441729
  • GDC-0084
  • GDC0084

Pharmacology

Indication

Not Available

Reduce drug development failure rates
Build, train, & validate machine-learning models
with evidence-based and structured datasets.
See how
Build, train, & validate predictive machine-learning models with structured datasets.
See how
Contraindications & Blackbox Warnings
Prevent Adverse Drug Events Today
Tap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.
Learn more
Avoid life-threatening adverse drug events with our Clinical API
Learn more
Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Improve decision support & research outcomes
With structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!
See the data
Improve decision support & research outcomes with our structured adverse effects data.
See a data sample
Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
P5DKZ70636
CAS number
1382979-44-3
InChI Key
LGWACEZVCMBSKW-UHFFFAOYSA-N
InChI
InChI=1S/C18H22N8O2/c1-18(2)16-22-12-14(25-3-6-27-7-4-25)23-13(11-9-20-17(19)21-10-11)24-15(12)26(16)5-8-28-18/h9-10H,3-8H2,1-2H3,(H2,19,20,21)
IUPAC Name
5-[6,6-dimethyl-4-(morpholin-4-yl)-6H,8H,9H-[1,4]oxazino[3,4-h]purin-2-yl]pyrimidin-2-amine
SMILES
CC1(C)OCCN2C1=NC1=C(N=C(N=C21)C1=CN=C(N)N=C1)N1CCOCC1

References

General References
Not Available
ChemSpider
57251291
BindingDB
50177662
ChEMBL
CHEMBL3813842
ZINC
ZINC000149645112

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2Active Not RecruitingTreatmentAdult Glioblastoma1
2Active Not RecruitingTreatmentDiffuse Intrinsic Pontine Gliomas (DIPG) / Diffuse Midline Glioma, H3 K27M-Mutant / Recurrent Diffuse Intrinsic Pontine Glioma / Recurrent Diffuse Midline Glioma, H3 K27M-Mutant / Recurrent WHO Grade III Glioma / WHO Grade 3 Glioma1
2RecruitingTreatmentBrain Metastases / CDK Gene Mutation / KRAS G12C Mutation / Metastatic Malignant Solid Neoplasms / NTRK Family Gene Mutation / PI3K Gene Mutation / ROS1 Gene Mutation1
2RecruitingTreatmentBreast Cancer1
2RecruitingTreatmentHigh Grade Glioma: Glioblastoma (GBM)1
2RecruitingTreatmentNon-Hodgkin Lymphoma of Extranodal Site / Primary Central Nervous System Lymphoma1
2, 3RecruitingTreatmentHigh Grade Glioma: Glioblastoma (GBM)1
1Active Not RecruitingTreatmentHealthy Subjects (HS)1
1CompletedTreatmentBrain and Central Nervous System Tumors1
1CompletedTreatmentGlioblastoma, Glioma1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.993 mg/mLALOGPS
logP1.62ALOGPS
logP1.32Chemaxon
logS-2.6ALOGPS
pKa (Strongest Acidic)15.83Chemaxon
pKa (Strongest Basic)3.98Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count9Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area117.1 Å2Chemaxon
Rotatable Bond Count2Chemaxon
Refractivity115.15 m3·mol-1Chemaxon
Polarizability40.86 Å3Chemaxon
Number of Rings5Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at May 20, 2019 14:57 / Updated at December 01, 2022 11:29